5-(3,3-Diethoxy-propyl)-2,9-dimethoxy-5H-dibenzo[cd,f]indol-4-one | 497179-75-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 5-(3,3-Diethoxy-propyl)-2,9-dimethoxy-5H-dibenzo[cd,f]indol-4-one
• 英文别名: 10-(3,3-Diethoxypropyl)-4,14-dimethoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1,3,5,7,9(16),12,14-heptaen-11-one
• CAS: 497179-75-6
• 化学式: C₂₄H₂₇NO₅
• 分子量: 409.482
• InChiKey: IBWORROOULLUSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(3,3-Diethoxy-propyl)-2,9-dimethoxy-5H-dibenzo[cd,f]indol-4-one 在 三氯化铁 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 生成 3-(2,9-Dimethoxy-4-oxo-4H-dibenzo[cd,f]indol-5-yl)-propionaldehyde
  参考文献：
  名称：

  Synthesis and biological evaluation of aristolactams

  摘要：

  A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00794-1
• 作为产物：
  描述：

  在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 生成 5-(3,3-Diethoxy-propyl)-2,9-dimethoxy-5H-dibenzo[cd,f]indol-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of aristolactams

  摘要：

  A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00794-1

文献信息

• Synthesis and biological evaluation of aristolactams
  作者：Axel Couture、Eric Deniau、Pierre Grandclaudon、Hélène Rybalko-Rosen、Stéphane Léonce、Bruno Pfeiffer、Pierre Renard

  DOI：10.1016/s0960-894x(02)00794-1

  日期：2002.12

  A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.