sodium ((2,3-difluorobenzyl) 5-cyclobutylamido-9-(4-chlorobenzamido)-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate | 1209013-04-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sodium ((2,3-difluorobenzyl) 5-cyclobutylamido-9-(4-chlorobenzamido)-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate
• CAS: 1209013-04-6
• 化学式: C₂₈H₃₀ClF₂N₂O₉*Na
• 分子量: 634.994
• InChiKey: OCXODRIGHZTMND-NIRDVSLLSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.83
• 重原子数：
  43.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  177.48
• 氢给体数：
  5.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  methyl ((2,3-difluorobenzyl) 5-cyclobutylamido-4,7,8-tri-O-acetyl-9-(4-chlorobenzamido)-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以49%的产率得到sodium ((2,3-difluorobenzyl) 5-cyclobutylamido-9-(4-chlorobenzamido)-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate
  参考文献：
  名称：

  Low Molecular Weight Antagonists of the Myelin-Associated Glycoprotein: Synthesis, Docking, and Biological Evaluation

  摘要：

  The Injured adult mammalian central nervous system Is all inhibitory environment for axon regeneration due to specific inhibitors,among them the myelin-associated glycoprotein (MAG), a member of the Siglec family (sialic-acid binding immunoglobulin-like lectin). In earlier Studies, we identified the lead structure5, which shows a 250-fold improved in vitro affinity for MAG compared to the tetrasaccharide binding epitope of GQ1b alpha (1), the best physiological MAG ligand described so far. By modifying the 2- and 5-position, the affinity of 5 could be further improved to the nanomolar range (-> 19a). Docking Studies to a homology model of MAG allowed the rationalization of the experimental binding properties. Finally, pharmacokinetic parameters (stability in the cerebrospinal fluid, logD and Permeation through the BBB) indicate the drug-like properties of the high-affinity antagonist 19a.

  DOI：

  10.1021/jm901517k