(±)-N-(tert-butyl)-2-phenyl-6-(piperidin-2-yl)imidazo[1,2-a]pyridin-3-amine hydrochloride | 1393330-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (±)-N-(tert-butyl)-2-phenyl-6-(piperidin-2-yl)imidazo[1,2-a]pyridin-3-amine hydrochloride
• CAS: 1393330-80-7
• 化学式: C₂₂H₂₈N₄*ClH
• 分子量: 384.952
• InChiKey: VOAIUFYZZUPJHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.45
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  41.36
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (±)-5-(piperidin-2-yl)pyridin-2-amine 在 盐酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙腈 为溶剂， 反应 40.0h， 生成 (±)-N-(tert-butyl)-2-phenyl-6-(piperidin-2-yl)imidazo[1,2-a]pyridin-3-amine hydrochloride
  参考文献：
  名称：

  Natural products as templates for bioactive compound libraries. 3*. novel heterocycles and peptidomimetics generated from anabasine by isocyanide-based multicomponent reactions

  摘要：

  Anabasine served as a starting material for the synthesis of two series of novel, drug-like compounds. On the one hand, anabasine was subjected to a direct Chichibabin amination and elaborated into medicinally relevant, racemic 6-(piperidin-2-yl)imidazo[1,2-a]pyridines via the Groebke-Blackburn reaction. On the other hand, anabasine was used as an amine for the Ugi reaction to provide novel non-racemic anabasine-containing 2-[(2-pyridin-3-yl)piperidin-1-yl]acetamide peptidomimetics with high diastereoselectivity.

  DOI：

  10.1007/s10593-012-1033-z