N-(aminoiminomethyl)-5,6-dihydro-6-oxo-4H-Pyrrolo [3,2,1-ij]quinoline-2-carboxamide methanesulfonate | 194869-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(aminoiminomethyl)-5,6-dihydro-6-oxo-4H-Pyrrolo [3,2,1-ij]quinoline-2-carboxamide methanesulfonate
• 英文别名: N-(diaminomethylidene)-9-oxo-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene-2-carboxamide;methanesulfonic acid
• CAS: 194869-66-4
• 化学式: CH₄O₃S*C₁₃H₁₂N₄O₂
• 分子量: 352.371
• InChiKey: OGJCBXNFJJXUPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.35
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
  申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

  公开号：EP0787728A1

  公开（公告）日：1997-08-06

  A compound which is a substituted guanidine derivative of formula (1): wherein each of R1, R2, R3 and R4, which are the same or different, is hydrogen or an organic group; each of Y1, Y2, Y3, Y4, Y5, Y6 and Y7, which are the same or different, is a single bond, -CH2-, -O-,-CO-, -C(=C(R11)R12- -S(O)n- or -N(R10)-, or any pairs represented by Y1 and Y2, Y2 and Y3, Y3 and Y4, Y4 and Y5, Y5 and Y6 or Y6 and Y7 represent -CH=CH- , and wherein at least two of Y1, Y2, Y3, Y4, Y5, Y6 and Y7 is other than a single bond; m is 0 or an integer of 1 to 5; and Z, each of which are the same or different when m is an integer of 2 to 5, is an organic substituent, or a pharmaceutically acceptable acid addition salt thereof, is useful as a therapeutic or prophylactic agent for diseases cause by acceleration of the sodium/proton (Na+/H+) exchange transport system such as hyperpiesia, arrhythmia, angina pectoris, hypercardia, diabetes, organopathies due to ischemia or ischemia re-perfusion, conditions due to cerebral ischemia, diseases caused by cell over-proliferation and diseases caused by trouble with endothelial cells.

  一种化合物，其为式（1）的取代的鸟氨酸衍生物：其中R1、R2、R3和R4中的每一个，相同或不同，均为氢或有机基团；Y1、Y2、Y3、Y4、Y5、Y6和Y7中的每一个，相同或不同，均为单键，-CH2-，-O-，-CO-，-C（=C（R11）R12-，-S（O）n-或-N（R10）-，或由Y1和Y2，Y2和Y3，Y3和Y4，Y4和Y5，Y5和Y6或Y6和Y7表示的任何一对均表示-CH=CH-，其中至少有两个Y1、Y2、Y3、Y4、Y5、Y6和Y7不是单键；m为0或1到5的整数；当m为2到5的整数时，Z均为有机取代基，或其药学上可接受的酸加成盐，用于治疗或预防由钠/质子（Na+/H+）交换转运系统加速引起的疾病，如高血压、心律失常、心绞痛、心肌过度收缩、糖尿病、缺血或再灌注引起的器官病变、脑缺血引起的疾病、细胞过度增殖引起的疾病以及内皮细胞问题引起的疾病。
• US5834454A
  申请人：——

  公开号：US5834454A

  公开（公告）日：1998-11-10
• US5977100A
  申请人：——

  公开号：US5977100A

  公开（公告）日：1999-11-02
• US6271251B1
  申请人：——

  公开号：US6271251B1

  公开（公告）日：2001-08-07