| 958870-12-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• CAS: 958870-12-7
• 化学式: C₁₇H₃₂N₈O₇
• 分子量: 460.49
• InChiKey: ILTVVFCPTVKIAS-HZMBPMFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.66
• 重原子数：
  32.0
• 可旋转键数：
  15.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  253.06
• 氢给体数：
  9.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  2-[3-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]propyl-(9H-fluoren-9-ylmethoxycarbonylamino)amino]acetic acid 、 Fmoc-甘氨酸 、 Fmoc-L-天冬氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成
  参考文献：
  名称：

  Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates

  摘要：

  In this study, a new class of phenolic tetrahydro-beta-carboline RGD peptidomimetic conjugates was designed and synthesized. The radical scavenging activities of these newly synthesized compounds 12a-c were evaluated in PC 12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. Compounds 12a-c were efficacious in a rat arterial thrombosis model, and were active in ADP- or PAF-induced in vitro platelet aggregation assays, which Suggests these compounds also possess anti-thrombotic activity. The beneficial effects of dual-acting agent 12c were demonstrated on the ischemia-reperfusion induced cardiac infarct size and oxidative change in an in vivo rat model. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.08.022