| 1401464-37-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1401464-37-6
• 化学式: C₁₄H₁₉N₃Se
• 分子量: 308.285
• InChiKey: VIDRVDGPWZXROS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  43.84
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3,5-二甲基-1-苯基吡唑 在 sodium tetrahydroborate 、 正丁基锂 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Synthesis, Characterization, and X-Ray Structures of 2-(3,5-Dimethylpyrazol-1-Yl)Phenyl-Based Organoselenium Compounds and Their Glutathione Peroxidase (Gpx) Like Activity

  摘要：

  The synthesis of a series of 2-(3,5-dimethylpyrazol-1-yl)phenyl-based organose-lenium compounds, (dmpzC(6)H(4)Se)(2) (1), dmpzC(6)H(4)SeR (dmpz = 3,5-dimethylpyrazol-1-yl; R = (CH2)(n)Y; Y = OH, NH2, and COOH), and dmpzC(6)H(4)SeX (X = Cl, Br, or I) is described. The compounds are characterized by IR, NMR (H-1, C-13{H-1}, Se-77{H-1}), and mass spectral (MS) data. The molecular structures of (dmpzC(6)H(4)Se)(2), dmpzC(6)H(4)SeCH(2)COOH, and dmpzC(6)H(4)SeCH(2)CH(2)OH have been established by X-ray crystallography. The two latter compounds are associated in the solid state through intermolecular hydrogen bonding between the OH proton and the pyrazolyl nitrogen atom of the adjacent molecule. Glutathione peroxidase (GPx) like catalytic activity of these compounds has been evaluated by using hydrogen peroxide (H2O2) as substrate and dithiothreitol (DTTred) as thiol cofactor in CD3OD, and the progress of the reaction was monitored by H-1 NMR spectroscopy. All the compounds exhibited the GPx-like catalytic activity. Among these, the ones containing alkylamino groups showed the best activity.

  DOI：

  10.1080/10426507.2012.686545