(2S,3R,4S,5R)-2-pyridin-3-yloxyoxane-3,4,5-triol | 1173283-69-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5R)-2-pyridin-3-yloxyoxane-3,4,5-triol
• CAS: 1173283-69-6
• 化学式: C₁₀H₁₃NO₅
• 分子量: 227.217
• InChiKey: ZMLXAOPQTZFQEE-RGOKHQFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  92
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2S,3R,4S,5R)-2-(pyridin-3-yloxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以93%的产率得到(2S,3R,4S,5R)-2-pyridin-3-yloxyoxane-3,4,5-triol
  参考文献：
  名称：

  Palladium-catalyzed C–C coupling: efficient preparation of new 5-thio-β-d-xylopyranosides as oral venous antithrombotic drugs

  摘要：

  First examples of a Suzuki and Stille cross-coupling reaction to prepare derivatives of pyridinyl 5-thio-beta-D-xylopyranosides are described. Some of these compounds are orally active in an animal model of venous thrombosis. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.050

文献信息

• Palladium-catalyzed C–C coupling: efficient preparation of new 5-thio-β-d-xylopyranosides as oral venous antithrombotic drugs
  作者：M. Bondoux、L. Mignon、K. Ou、P. Renaut、D. Thomas、V. Barberousse

  DOI：10.1016/j.tetlet.2009.04.050

  日期：2009.7

  First examples of a Suzuki and Stille cross-coupling reaction to prepare derivatives of pyridinyl 5-thio-beta-D-xylopyranosides are described. Some of these compounds are orally active in an animal model of venous thrombosis. (c) 2009 Elsevier Ltd. All rights reserved.