7-chloro-N-(3-(cyclopentylamino)-3-oxo-1-phenylpropyl)-6-fluoro-4-oxo-1-(prop-2-yn-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide | 1169935-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-N-(3-(cyclopentylamino)-3-oxo-1-phenylpropyl)-6-fluoro-4-oxo-1-(prop-2-yn-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
• 英文别名: N-(2-N-cyclopentylcarbamoyl-1-phenylethyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-propargyl-1,8-naphthyridine-3-carboxamide；7-chloro-N-[3-(cyclopentylamino)-3-oxo-1-phenylpropyl]-6-fluoro-4-oxo-1-prop-2-ynyl-1,8-naphthyridine-3-carboxamide
• CAS: 1169935-37-8
• 化学式: C₂₆H₂₄ClFN₄O₃
• 分子量: 494.953
• InChiKey: VOPPHZPYEWWGPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  91.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-amino-N-cyclopentyl-3-phenyl-propionamide 、 7-Chloro-6-fluoro-4-oxo-1-prop-2-ynyl-1,8-naphthyridine-3-carbonyl chloride 以 二氯甲烷 为溶剂， 反应 2.0h， 以67.6%的产率得到7-chloro-N-(3-(cyclopentylamino)-3-oxo-1-phenylpropyl)-6-fluoro-4-oxo-1-(prop-2-yn-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
  参考文献：
  名称：

  1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

  摘要：

  A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.015