(Z)-2,2-difluoro-14-nonadecen-1-ol | 565225-69-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: (Z)-2,2-difluoro-14-nonadecen-1-ol
• CAS: 565225-69-6
• 化学式: C₁₉H₃₆F₂O
• 分子量: 318.491
• InChiKey: AUZBVSXWTOWCNT-WAYWQWQTSA-N

物化性质

• 沸点：
  393.8±27.0 °C(Predicted)
• 密度：
  0.925±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (Z)-2,2-difluoro-14-nonadecen-1-ol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以42%的产率得到(Z)-2,2-Difluoro-nonadec-14-enal
  参考文献：
  名称：

  New fluorinated derivatives as esterase inhibitors. Synthesis, hydration and crossed specificity studies

  摘要：

  A variety of new fluorinated chemicals have been prepared for the first time and tested as inhibitors of esterases, one of the main enzymes involved in pheromone catabolism, in two economically important pests, the Egyptian armyworm Spodoptera littoralis (SL) and the Mediterranean corn borer Sesamia nonagrioides (SN). Using the respective major component of the pheromone as substrate, the K-m and V-max of the antennal esterase of both insects resulted to be 5.66 x 10(-4) M and 8.47 x 10(-6) Mmin(-1) for SL and 1.61 x 10(-7) M and 1.25 x 10(-7) Mmin(-1) for SN, pointing out that SN esterase has a higher affinity for its corresponding substrate than SL. In general, the trifluoromethyl ketones (TFMKs) exhibited higher inhibitory potency than the corresponding difluoromethyl ketones (DFMKs) or difluoroaldehydes (DFAs). The compounds appeared to hydrate differently in aqueous solution, the extent of hydration following the order: alpha,alpha-DFMKs

  DOI：

  10.1016/s0968-0896(02)00467-4
• 作为产物：
  描述：

  (Z)-2,2-Difluoro-nonadec-14-enoic acid ethyl ester 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以69%的产率得到(Z)-2,2-difluoro-14-nonadecen-1-ol
  参考文献：
  名称：

  New fluorinated derivatives as esterase inhibitors. Synthesis, hydration and crossed specificity studies

  摘要：

  A variety of new fluorinated chemicals have been prepared for the first time and tested as inhibitors of esterases, one of the main enzymes involved in pheromone catabolism, in two economically important pests, the Egyptian armyworm Spodoptera littoralis (SL) and the Mediterranean corn borer Sesamia nonagrioides (SN). Using the respective major component of the pheromone as substrate, the K-m and V-max of the antennal esterase of both insects resulted to be 5.66 x 10(-4) M and 8.47 x 10(-6) Mmin(-1) for SL and 1.61 x 10(-7) M and 1.25 x 10(-7) Mmin(-1) for SN, pointing out that SN esterase has a higher affinity for its corresponding substrate than SL. In general, the trifluoromethyl ketones (TFMKs) exhibited higher inhibitory potency than the corresponding difluoromethyl ketones (DFMKs) or difluoroaldehydes (DFAs). The compounds appeared to hydrate differently in aqueous solution, the extent of hydration following the order: alpha,alpha-DFMKs

  DOI：

  10.1016/s0968-0896(02)00467-4