2-methyl 4-S-[(2-deoxy-2-thioacetamido-β-D-glucopyranosyl)]-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-thiazoline | 1164151-23-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl 4-S-[(2-deoxy-2-thioacetamido-β-D-glucopyranosyl)]-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-thiazoline
• 英文别名: N-[(2S,3R,4R,5S,6R)-2-[[(3aR,5R,6S,7R,7aR)-7-hydroxy-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazol-6-yl]sulfanyl]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanethioamide
• CAS: 1164151-23-8
• 化学式: C₁₆H₂₆N₂O₇S₃
• 分子量: 454.59
• InChiKey: SHWGRZNBQWAUOZ-KSKNGZLJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  227
• 氢给体数：
  6
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-methyl-4-S-[(3,4,6-tri-O-acetyl-2-deoxy-2-thioacetamido-β-D-glucopyranosyl)]-(3,6-di-O-benzoyl-1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-thiazoline 在 甲醇 、 sodium methylate 作用下， 反应 16.0h， 以98%的产率得到2-methyl 4-S-[(2-deoxy-2-thioacetamido-β-D-glucopyranosyl)]-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-thiazoline
  参考文献：
  名称：

  Synthesis and conformational analysis of glycomimetic analogs of thiochitobiose

  摘要：

  The synthesis of six analogs of N,N'-diacetylchitobiose is reported, including a novel transglycosylation reaction for the preparation of S-aryl thioglycosides. The conformations of the compounds were studied by a combination of NMR spectroscopy and molecular modeling, using force field calculations. In the case of the S-aryl thioglycosides with exclusively S-glycosidic linkages, dihedral angles of the disaccharidic S-glycosidic bonds, Phi' and Psi' and of the S-arylglycoside bonds, Phi and Psi, were found to be similar, whereas they were different in mixed glycosides and in a thiazoline derivative. An adequate correlation between the calculated H,H-distances of the local minima and the measured NOE contacts was achieved by applying population-weighted averages over participating conformers based on weighted relative energies. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.067

文献信息

• Synthesis and conformational analysis of glycomimetic analogs of thiochitobiose
  作者：Anja Fettke、Dirk Peikow、Martin G. Peter、Erich Kleinpeter

  DOI：10.1016/j.tet.2009.03.067

  日期：2009.5

  The synthesis of six analogs of N,N'-diacetylchitobiose is reported, including a novel transglycosylation reaction for the preparation of S-aryl thioglycosides. The conformations of the compounds were studied by a combination of NMR spectroscopy and molecular modeling, using force field calculations. In the case of the S-aryl thioglycosides with exclusively S-glycosidic linkages, dihedral angles of the disaccharidic S-glycosidic bonds, Phi' and Psi' and of the S-arylglycoside bonds, Phi and Psi, were found to be similar, whereas they were different in mixed glycosides and in a thiazoline derivative. An adequate correlation between the calculated H,H-distances of the local minima and the measured NOE contacts was achieved by applying population-weighted averages over participating conformers based on weighted relative energies. (C) 2009 Elsevier Ltd. All rights reserved.