2-naphthylmethyl-O-(methyl-2,3-di-O-benzoyl-4-O-levulinoyl-β-D-glucopyranosyluronate)-(1->3)-2-acetamido-4-O-benzoyl-2-deoxy-β-D-galactopyranoside | 1225203-36-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-naphthylmethyl-O-(methyl-2,3-di-O-benzoyl-4-O-levulinoyl-β-D-glucopyranosyluronate)-(1->3)-2-acetamido-4-O-benzoyl-2-deoxy-β-D-galactopyranoside
• CAS: 1225203-36-0
• 化学式: C₅₂H₅₁NO₁₇
• 分子量: 961.973
• InChiKey: UNCDKPIQMFPBEF-KQJZAMKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.82
• 重原子数：
  70.0
• 可旋转键数：
  18.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  234.82
• 氢给体数：
  2.0
• 氢受体数：
  17.0

反应信息

• 作为产物：
  描述：

  2-naphthylmethyl O-(methyl-2,3-di-O-benzoyl-4-O-levulinoyl-β-D-glucopyranosyluronate)-(1->3)-4-O-benzoyl-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside 在 铜 、 锌 作用下， 以 溶剂黄146 为溶剂， 反应 7.5h， 以85%的产率得到2-naphthylmethyl-O-(methyl-2,3-di-O-benzoyl-4-O-levulinoyl-β-D-glucopyranosyluronate)-(1->3)-2-acetamido-4-O-benzoyl-2-deoxy-β-D-galactopyranoside
  参考文献：
  名称：

  Efficient alternative for the reduction of N-trichloroacetyl groups in synthetic chondroitin oligosaccharide intermediates

  摘要：

  An efficient alternative for the reduction of N-trichloroacetyl groups in chondroitin oligosaccharides is reported. It involves the use of Zn-Cu couple in acetic acid, and Was Successfully applied to a large panel of synthetic intermediates useful for the preparation of chondroitin oligomers, a class of natural products with numerous relevant biological functions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.005