7-hydroxycarbonyl-2,4,9-trithiaadamantane; β-cyclodextrine; inclusion complex of | 824413-86-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-hydroxycarbonyl-2,4,9-trithiaadamantane; β-cyclodextrine; inclusion complex of
• CAS: 824413-86-7
• 化学式: C₈H₁₀O₂S₃*C₄₂H₇₀O₃₅
• 分子量: 1369.36
• InChiKey: NTAROVHLGHIWQR-ZQOBQRRWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2,4,9-trithiaadamantane-7-carboxylic acid 、 β-环糊精 以 重水 为溶剂， 生成 7-hydroxycarbonyl-2,4,9-trithiaadamantane; β-cyclodextrine; inclusion complex of
  参考文献：
  名称：

  [EN] 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE AND RELATED METHODS
  [FR] 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE ET PROCEDES AFFERENTS

  摘要：

  公开号：

  WO2005003089A3

文献信息

• Solid phase synthesis of 1,5-disubstituted pyrazole-4-hydroxamic acids and pyrazole-4-carboxamides via direct amidation of β-ketoesters
  作者：Weixu Zhai、Samuel W. Gerritz、Michael J. Sofia

  DOI：10.1016/j.tetlet.2011.11.031

  日期：2012.1

  This manuscript describes a convenient method for the direct amidation of methyl and ethyl β-ketoesters to generate solid-supported β-ketohydroxamates or β-ketoamides and the application of this methodology to the synthesis of 1,5-disubstituted pyrazole-4-hydroxamic acids and pyrazole-4-carboxamides.

  该手稿描述了直接酰胺化甲基和乙基β-酮酸酯以生成固体负载的β-酮异羟肟酸酯或β-酮酰胺的简便方法，并将该方法应用于1,5-二取代的吡唑-4-异羟肟酸的合成和吡唑-4-羧酰胺。
• [EN] CARBOLINE AND BETACARBOLINE DERIVATIVES FOR USE AS HDAC ENZYME INHIBITORS<br/>[FR] DERIVES DE CARBOLINE ET DE BETACARBOLINE INHIBITEURS DE L'ENZYME HDAC
  申请人：CHROMA THERAPEUTICS LTD

  公开号：WO2004113336A1

  公开（公告）日：2004-12-29

  Compounds of formula (IA) and (IB) are inhibitors of histone deacetylase activity and useful for the treatment of, inter alia, cancers: wherein fused rings A1 and A2 are optionally substituted; linker radical R1 represents a radical of formula

  式（IA）和（IB）的化合物是组蛋白去乙酰化酶活性的抑制剂，用于治疗癌症等疾病：其中融合的环A1和A2可以选择性地被取代；连接基团R1代表一个公式的基团。
• Method for Activation and Recycling of Trityl Resins
  作者：Itedale Namro Redwan、Morten Grøtli

  DOI：10.1021/jo300598d

  日期：2012.8.17

  anilines onto a polystyrene triphenylmethyl (trityl) resin. High loadings were obtained in a matter of minutes by treating resin-bound trityl chloride with triethyloxonium tetrafluoroborate followed by alcohols or anilines. Yields were comparable or better than known literature methods. Recycling of the recovered resin was also possible using the developed method.

  本说明描述了将醇和苯胺装载到聚苯乙烯三苯甲基（三苯甲基）树脂上的快速而温和的策略。通过用四氟硼酸三乙基氧鎓，然后用醇或苯胺处理与树脂结合的三苯甲基氯，在数分钟内获得高负载量。产量与已知的文献方法相当或更好。使用开发的方法也可以回收回收的树脂。
• Substituted hexahydropyrazino (1,2-a) pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments
  申请人：Flohr Stefanie

  公开号：US20050004131A1

  公开（公告）日：2005-01-06

  Substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

  取代的六氢吡嗪[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其用作药物。本发明涉及取代的六氢吡嗪[1,2-a]嘧啶-4,7-二酮衍生物以及其生理耐受盐和生理功能衍生物。描述了具有以下式I的化合物，其中基团具有所述含义，以及其生理耐受盐和制备它们的方法。这些化合物例如适用于作为厌食剂。
• WO2006/117549
  申请人：——

  公开号：——

  公开（公告）日：——