2-[4-(4-Acetylbenzyl)-3,5-dichlorophenyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione | 1146445-34-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[4-(4-Acetylbenzyl)-3,5-dichlorophenyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
• 英文别名: 2-[4-[(4-Acetylphenyl)methyl]-3,5-dichlorophenyl]-4-methyl-1,2,4-triazine-3,5-dione
• CAS: 1146445-34-2
• 化学式: C₁₉H₁₅Cl₂N₃O₃
• 分子量: 404.252
• InChiKey: OKWNPNYIHMVOIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  70
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 1,2,4-Triazine-3,5-dione derivatives as anticoccidial agents
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0831088A1

  公开（公告）日：1998-03-25

  The present invention relates to compounds represented by the formula: wherein R1 is (1) an optionally substituted alkyl group which may be bonded through a hetero atom, (2) an optionally substituted acyl group, (3) an alkylsulfonyl group, (4) an alkylsulfinyl group, or (5) an optionally substituted sulfamoyl group; A is -N= or -CH=; R2 is a hydrogen atom or an alkyl group which may optionally be substituted with halogen and which may be bonded through a hetero atom; X1 is halogen or a lower alkyl group; X2 is a hydrogen atom or a fluorine atom; R3 is a hydrogen atom, halogen or a lower alkyl group; and R4 is a hydrogen atom, an optionally substituted alkyl group or an acyl group, provided that when R1 is (1) a C1-4 alkanoyl group, (2) benzoyl, (3) trifluoroacetyl, (4) sulfamoyl which may optionally be substituted with a C1-4 alkyl group, (5) a C1-4 alkyl group which may optionally be substituted with hydroxy, halogen or a C1-3 alkoxy group, (6) amino which is substituted with a C1-4 alkyl group, A is -CH=, R2 is a hydrogen atom, X1 is a chlorine atom, R3 is a chlorine atom, and X2 is a hydrogen atom, then R4 is an optionally substituted alkyl group or an optionally substituted acyl group; or salts thereof, their production and use thereof. These compounds and salts thereof are useful as anti-protozoal agents.

  本发明涉及由式表示的化合物： 其中R1是(1)任选取代的烷基，该烷基可通过杂原子键合，(2)任选取代的酰基，(3)烷基磺酰基，(4)烷基亚磺酰基，或(5)任选取代的氨基磺酰基；A是-N＝或-CH＝；R2是氢原子或烷基，该烷基可任选被卤素取代，并可通过杂原子键合； X1 是卤素或低级烷基； X2 是氢原子或氟原子； R3 是氢原子、卤素或低级烷基； R4是氢原子、任选取代的烷基或酰基，但当R1是(1)C1-4烷酰基，(2)苯甲酰基，(3)三氟乙酰基，(4)可任选被C1-4烷基取代的氨基磺酰基，(5)可任选被羟基、卤素或C1-3烷基取代的C1-4烷基、(6) 被 C1-4 烷基取代的氨基，A 为-CH=，R2 为氢原子，X1 为氯原子，R3 为氯原子，X2 为氢原子，则 R4 为任选取代的烷基或任选取代的酰基；或其盐类，以及它们的生产和使用。这些化合物及其盐类可用作抗原虫制剂。
• US5985875A
  申请人：——

  公开号：US5985875A

  公开（公告）日：1999-11-16