11-[2,3-Bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-2-[9-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[5-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-4-methylpentyl]-8-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-8-methylnonyl]-6-[5-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-4-methylpentyl]-10-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-10-methylundecan-1-ol | 1424713-08-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-[2,3-Bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-2-[9-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[5-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-4-methylpentyl]-8-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-8-methylnonyl]-6-[5-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-4-methylpentyl]-10-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-10-methylundecan-1-ol
• CAS: 1424713-08-5
• 化学式: C₁₅₈H₂₈₆O₅₇
• 分子量: 3097.97
• InChiKey: DAKLBQRGNCWCQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  215
• 可旋转键数：
  113
• 环数：
  16.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  537
• 氢给体数：
  1
• 氢受体数：
  57

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 、 溶剂黄146 作用下， 以 丙酮 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 120.0h， 以84%的产率得到11-[2,3-Bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-2-[9-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[5-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-4-methylpentyl]-8-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-8-methylnonyl]-6-[5-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxy]-4-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-4-methylpentyl]-10-[2,3-bis[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]propoxymethyl]-10-methylundecan-1-ol
  参考文献：
  名称：

  Versatile Synthesis of Amphiphilic Oligo(Aliphatic-Glycerol) Layer-Block Dendrons with Different Hydrophilic-Lipophilic Balance Values

  摘要：

  A series of amphiphilic oligo(glycerol-aliphatic) layer-blocked dendrons with different hydrophilic-lipophilic balance values (3.5-15.0) was prepared for use in controlled drug delivery and self-assembly studies. The synthetic strategies involved first a convergent growth of the inner hydrophobic sector followed by a divergent growth of the outer hydrophilic sector.

  DOI：

  10.1055/s-0032-1317929