| 1050411-80-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1050411-80-7
• 化学式: C₃₁H₄₈O₁₄
• 分子量: 644.714
• InChiKey: OWPOBWLNJNTZPG-IAHZQKLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  45.0
• 可旋转键数：
  10.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  129.22
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  在 溶剂黄146 作用下， 反应 15.0h， 以99%的产率得到
  参考文献：
  名称：

  Synthesis of Ether-Linked Oligoribo- and Xylonucleosides from 3,5′-Ether-Linked Pseudosaccharides

  摘要：

  First examples of di- and trinucleosides with ribose and xylose stereochemistry having internucleoside ether linkage were synthesized from 3,5'-ether-linked pseudosaccharides. The synthetic protocol involved removal of 1,2-isopropylidene protecting groups front the pseudosaccharides followed by acetylation and a subsequent Vorbruggen transglycosylation with uracil and N-benzoylaminopurine. The synthetic strategy is potentially important for the development of RNA analogues with internucleoside ether linkage.

  DOI：

  10.1021/jo8007429
• 作为产物：
  描述：

  ((3aR,5R,6R,6aR)-6-(((3aR,5R,6R,6aR)-6-(allyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methoxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl methanesulfonate 、 1,2:5,6-二异亚丙基-alpha-D-异呋喃糖 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 水 为溶剂， 反应 70.0h， 以0.45 g的产率得到
  参考文献：
  名称：

  Synthesis of Ether-Linked Oligoribo- and Xylonucleosides from 3,5′-Ether-Linked Pseudosaccharides

  摘要：

  First examples of di- and trinucleosides with ribose and xylose stereochemistry having internucleoside ether linkage were synthesized from 3,5'-ether-linked pseudosaccharides. The synthetic protocol involved removal of 1,2-isopropylidene protecting groups front the pseudosaccharides followed by acetylation and a subsequent Vorbruggen transglycosylation with uracil and N-benzoylaminopurine. The synthetic strategy is potentially important for the development of RNA analogues with internucleoside ether linkage.

  DOI：

  10.1021/jo8007429