Methyl 4-hydroxy-2-methylquinoline-7-carboxylate | 1150618-19-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 4-hydroxy-2-methylquinoline-7-carboxylate
• 英文别名: methyl 2-methyl-4-oxo-1H-quinoline-7-carboxylate
• CAS: 1150618-19-1
• 化学式: C₁₂H₁₁NO₃
• 分子量: 217.22
• InChiKey: KSJSSSXPGHDQFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20180009784A1

  公开（公告）日：2018-01-11

  This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein T, J, R, R 4 , R q , o, R A , W and R B and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, and/or T-cell mediated autoimmune disease.