6^A-O-phosphono-α-cyclodextrin | 752965-17-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6^A-O-phosphono-α-cyclodextrin
• 英文别名: [(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-31,32,33,34,35,36,37,38,39,40,41,42-dodecahydroxy-10,15,20,25,30-pentakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontan-5-yl]methyl dihydrogen phosphate
• CAS: 752965-17-6
• 化学式: C₃₆H₆₁O₃₃P
• 分子量: 1052.83
• InChiKey: LUSBQMSVAHGUBP-RWMJIURBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -14
• 重原子数：
  70
• 可旋转键数：
  8
• 环数：
  22.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  521
• 氢给体数：
  19
• 氢受体数：
  33

反应信息

• 作为产物：
  描述：

  6^A-O-(diphenoxyphosphoryl)-α-cyclodextrin 在 platinum(IV) oxide 水 、 氢气 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以196 mg的产率得到6^A-O-phosphono-α-cyclodextrin
  参考文献：
  名称：

  Effective synthesis of negatively charged cyclodextrins. Selective access to phosphate cyclodextrins

  摘要：

  We report the selective preparation of alpha- and beta-cyclodextrins bearing one and two phosphate moieties on the primary rim. These compounds were prepared by selective O-debenzylation of fully protected derivatives, followed by phosphorylation and deprotection. The synthesis of an a-cyclodextrin with both, a carboxylic group and a phosphate moiety on primary positions is also described. Title compounds are examples of negatively charged cyclodextrins that might be of interest in studying the complexation of cationic guests. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.094

文献信息

• [EN] CONJUGATES AND CONJUGATING REAGENTS<br/>[FR] CONJUGUÉS ET RÉACTIFS DE CONJUGAISON
  申请人：POLYTHERICS LTD

  公开号：WO2017199046A1

  公开（公告）日：2017-11-23

  A conjugate of a protein or peptide conjugated to a therapeutic, diagnostic or labelling agent via a linker, in which the linker includes a protein or peptide bonding portion having the general formula: (I), in which Pr represents said protein or peptide, each Nu represents a nucleophile present in or attached to the protein or peptide, each of A and B independently represents a C1-4alkylene or alkenylene chain, and W' represents an electron withdrawing group or a group obtained by reduction of an electron withdrawing group; and in which the linker also includes a cyclodextrin. The invention also provides reagents for making such conjugates.

  蛋白质或多肽与治疗性、诊断或标记试剂通过连接剂共价结合的共轭物，其中连接剂包括具有以下通式的蛋白质或多肽键合部分：（I），其中Pr代表所述蛋白质或多肽，每个Nu代表存在于或附着于蛋白质或多肽中的亲核基团，每个A和B独立地代表C1-4烷基或烯基链，W'代表电子提取基团或通过还原电子提取基团获得的基团; 连接剂还包括环糊精。本发明还提供制备此类共轭物的试剂。
• Therapeutic patch useful for the treatment of hemorrhoids
  申请人：——

  公开号：US20020192273A1

  公开（公告）日：2002-12-19

  The present invention provides an adhesive patch that includes a flexible backing having a front side and a back side. A therapeutic formulation is positioned on at least a portion of the front side of the backing, in at least a portion of the front side of the backing, or on and in at least a portion of the front side of the backing. The therapeutic formulation includes a vasoconstrictor, a solvent that dissolves the vasoconstrictor, and a pressure sensitive adhesive. The present invention also provides methods of medical use that employ the patch of the present invention. Such uses include, e.g., treating or preventing hemorrhoids in a mammal, providing relief from the discomfort associated with hemorrhoids, providing post-operative relief from discomfort associated with the surgical treatment of hemorrhoids, treating or preventing a bacterial infection associated with hemorrhoids, preventing a bacterial infection associated with the surgical treatment of hemorrhoids, absorbing exudate, blood, or a combination thereof from the region of the anus of a mammal inflicted with hemorrhoids, and absorbing exudate, blood, or a combination thereof from the region of the anus of a mammal during the post-operative treatment of hemorrhoids.

  本发明提供了一种粘性贴片，它包括具有正面和背面的柔性背衬。治疗配方至少位于背衬正面的一部分、背衬正面的至少一部分或背衬正面的至少一部分。治疗配方包括血管收缩剂、溶解血管收缩剂的溶剂和压敏粘合剂。本发明还提供了采用本发明贴片的医疗使用方法。这些用途包括治疗或预防哺乳动物的痔疮，缓解与痔疮相关的不适，缓解与痔疮手术治疗相关的术后不适，治疗或预防与痔疮相关的细菌感染、防止与痔疮手术治疗相关的细菌感染，吸收患痔疮的哺乳动物肛门区域的渗出物、血液或其组合，以及在痔疮术后治疗期间吸收哺乳动物肛门区域的渗出物、血液或其组合。
• Psoriasis patch
  申请人：——

  公开号：US20030077316A1

  公开（公告）日：2003-04-24

  The present invention provides a water insoluble, protective, adhesive skin patch useful for treating or preventing psoriasis, dermatitis, and/or eczema. The adhesive patch includes a backing that is treated with a sizing agent (e.g., a fluorocarbon solution, a silicone-containing compound, or a combination thereof). The present invention also provides a method for treating or preventing at least one of psoriasis, dermatitis, and eczema in a mammal (e.g., human) and a method for exfoliating the skin surface of a mammal.

  本发明提供了一种用于治疗或预防牛皮癣、皮炎和/或湿疹的不溶于水的保护性粘合皮肤贴片。该粘合性皮肤贴片包括一个用施胶剂（如碳氟化合物溶液、含硅化合物或它们的组合）处理过的衬底。本发明还提供了一种治疗或预防哺乳动物（如人类）牛皮癣、皮炎和湿疹中至少一种的方法，以及一种去除哺乳动物皮肤表面角质的方法。
• METHOD FOR TREATING SKIN DISORDERS WITH XANTHOPHYLLS
  申请人：Nu-Tein Co., Inc.

  公开号：EP1827408A1

  公开（公告）日：2007-09-05
• TOPICAL SKIN PATCH CONTAINING XANTHOPHYLLS
  申请人：Nu-Tein Co., Inc.

  公开号：EP1827400A2

  公开（公告）日：2007-09-05