{(S)-2-[1-(2-Cyano-ethyl)-1H-tetrazol-5-ylmethyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester | 886990-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: {(S)-2-[1-(2-Cyano-ethyl)-1H-tetrazol-5-ylmethyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
• CAS: 886990-30-3
• 化学式: C₁₆H₂₈N₆O₂
• 分子量: 336.437
• InChiKey: CKKRXPQJUIYKTF-ZDUSSCGKSA-N

反应信息

• 作为反应物：
  描述：

  {(S)-2-[1-(2-Cyano-ethyl)-1H-tetrazol-5-ylmethyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 [(S)-4-Methyl-2-(1H-tetrazol-5-ylmethyl)-pentyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Carboxylate bioisosteres of gabapentin

  摘要：

  A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha(2)-delta protein. Further characterization Of alpha(2)-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.016
• 作为产物：
  描述：

  在 叠氮基三甲基硅烷 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 生成 {(S)-2-[1-(2-Cyano-ethyl)-1H-tetrazol-5-ylmethyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Carboxylate bioisosteres of gabapentin

  摘要：

  A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha(2)-delta protein. Further characterization Of alpha(2)-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.016