| 1198179-72-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• CAS: 1198179-72-4
• 化学式: C₁₇H₁₇BrO₂S
• 分子量: 365.291
• InChiKey: LRSCBPYOMBZEFV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-乙酰基-3-溴噻吩 、 4-Methoxy-2,3,5-trimethylbenzaldehyde 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以86%的产率得到
  参考文献：
  名称：

  Synthesis and Characterization of Some Novel 3-Bromo-2-acetylthiophene Chalcones and Biological Evaluation of Their Ethyl-4-(3-bromothien-2-yl)-2-oxo-6-(aryl)cyclohex-3-ene-1-carboxylate Derivatives

  摘要：

  Novel chalcones 1-(3-bromothien-2-yl)-3-(aryl) prop-2-en-1-ones derived from 3-bromo- 2-acetylthiophene and their cyclization product with ethylacetoacetate such as 4-(3-bromothien-2-yl)-2-oxo-6-(aryl)cyclohex-3-ene-1-carboxylate derivatives were synthesized and studied by X-ray, analytical, and spectralmethods. Compounds were screened for their anti-inflammatory, analgesic, and antimicrobial activities. The compound ethyl-4-(3-bromothien-2-yl)-2-oxo-6-(4-propoxyphenyl) cyclohex-3-ene-1-carboxylate5c exhibited promising anti-inflammatory, analgesic and antibacterial activities.

  DOI：

  10.1080/10426500802414189