tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-(2-tributylstannylethenyl)-1,3-dioxan-4-yl]acetate | 143827-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-(2-tributylstannylethenyl)-1,3-dioxan-4-yl]acetate
• CAS: 143827-07-0
• 化学式: C₂₆H₅₀O₄Sn
• 分子量: 545.391
• InChiKey: WEAMRWXFLQQMSZ-XGUKMECDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.57
• 重原子数：
  31
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-(4-fluorophenyl)pentan-3-yl)phenyl trifluoromethanesulfonate 、 tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-(2-tributylstannylethenyl)-1,3-dioxan-4-yl]acetate 在 bis-triphenylphosphine-palladium(II) chloride 、 三苯基膦 、 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors

  摘要：

  Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton. Among them, sodium (E,3R,5S)-7-(2-(4-fluorophenyl)-4-(3-phenylpentan-3-yl)phenyl)-3,5-dihydroxy-hept-6-enoate showed potent HMG-CoA reductase-inhibitory activity comparable with that of clinically useful mevastatin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.100

文献信息

• Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors
  作者：Shinnosuke Hosoda、Daisuke Matsuda、Hiroshi Tomoda、Mariko Hashimoto、Hiroshi Aoyama、Yuichi Hashimoto

  DOI：10.1016/j.bmcl.2009.05.100

  日期：2009.8

  Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton. Among them, sodium (E,3R,5S)-7-(2-(4-fluorophenyl)-4-(3-phenylpentan-3-yl)phenyl)-3,5-dihydroxy-hept-6-enoate showed potent HMG-CoA reductase-inhibitory activity comparable with that of clinically useful mevastatin. (C) 2009 Elsevier Ltd. All rights reserved.