5-(benzyloxy)-2-methylbenzaldehyde | 1450931-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(benzyloxy)-2-methylbenzaldehyde
• 英文别名: 2-methyl-5-phenylmethoxybenzaldehyde
• CAS: 1450931-38-0
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: WGJUVTHJCMTGRY-UHFFFAOYSA-N

物化性质

• 沸点：
  375.8±27.0 °C(Predicted)
• 密度：
  1.119±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(benzyloxy)-2-methylbenzaldehyde 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 30.0h， 生成 ethyl 3-(5-hydroxy-2-methylphenyl)propanoate
  参考文献：
  名称：

  EP2816032

  摘要：

  公开号：
• 作为产物：
  描述：

  5-(benzyloxy)-2-methylbenzoic acid 在 borane tetrahydrofuran 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 4.83h， 生成 5-(benzyloxy)-2-methylbenzaldehyde
  参考文献：
  名称：

  EP2816032

  摘要：

  公开号：

文献信息

• ANTI-HIV COMPOUNDS
  申请人：Prosetta Antiviral, Inc.

  公开号：US20160168100A1

  公开（公告）日：2016-06-16

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.

  这项发明提供了用于治疗病毒感染的四氢异喹啉等化合物，含有这类化合物的药物配方，以及抑制病毒（如HIV）复制或治疗疾病（如艾滋病）的方法。
• BETA-SUBSTITUTED GAMMA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS
  申请人：QUADRIGA BIOSCIENCES, INC.

  公开号：US20150218085A1

  公开（公告）日：2015-08-06

  β-Substituted γ-amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates, capable of passing through the blood-brain barrier, and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres and methods of using the compounds for treating tumors are also disclosed. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres exhibit an improved selectivity toward tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres exhibit an increased efficacy on a variety of tumor types.

  β-取代的γ-氨基酸，β-取代的γ-氨基酸衍生物，以及β-取代的γ-氨基酸类似物和（生物）同位素及其作为化疗药物的用途被披露。这些β-取代的γ-氨基酸衍生物和β-取代的γ-氨基酸类似物和（生物）同位素是选择性LAT1/4F2hc底物，能够穿过血脑屏障，并在表达LAT1/4F2hc转运蛋白的肿瘤中表现出快速摄取和保留。还披露了合成β-取代的γ-氨基酸衍生物和β-取代的γ-氨基酸类似物和（生物）同位素的方法以及使用这些化合物治疗肿瘤的方法。这些β-取代的γ-氨基酸衍生物和β-取代的γ-氨基酸类似物和（生物）同位素表现出对表达LAT1/4F2hc转运蛋白的肿瘤细胞的改进选择性，并在体内给予受试者时在癌细胞中积累。这些β-取代的γ-氨基酸衍生物和β-取代的γ-氨基酸类似物和（生物）同位素在多种肿瘤类型上表现出增加的疗效。
• [EN] DIRECT AMPK ACTIVATOR COMPOUNDS<br/>[FR] COMPOSÉS ACTIVATEURS DIRECTS DE L'AMPK
  申请人：NESTLE SA

  公开号：WO2019228794A1

  公开（公告）日：2019-12-05

  The present invention relates to a compound having general formula I for use in the activation of AMPK. A composition comprising said compound for use in the activation of AMPK is also provided. Said compounds are 9,10 dihydrophenanthrenes, in particular selected from the group consisting of: (i) Lusianthridin i.e. 7- Methoxy-9,10-dihydrophenanthrene-2,5-diol, (ii) 7-Methoxy-9,10- dihydrophenanthrene-2,3,5-triol, (iii) 9,10-dihydrophenanthrene-2,5- diol, (iv) 9,10-Dihydrophenanthrene-2,4,7-triol (v) 9,10-Dihydro-7- methoxy-3,5-phenanthrenediol, and the activation of AMPK improves the condition, disorder, or disease related to cardiometabolic health, obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular disease, and cancer.

  本发明涉及具有一般式I的化合物，用于激活AMPK。还提供了一种包含所述化合物的组合物，用于激活AMPK。所述化合物为9,10-二氢菲烯，特别是选自以下组合的一种：（i）卢西昂三醇，即7-甲氧基-9,10-二氢菲烯-2,5-二醇，（ii）7-甲氧基-9,10-二氢菲烯-2,3,5-三醇，（iii）9,10-二氢菲烯-2,5-二醇，（iv）9,10-二氢菲烯-2,4,7-三醇，（v）9,10-二氢-7-甲氧基-3,5-菲烯二醇，激活AMPK改善与心脏代谢健康、肥胖、2型糖尿病、非酒精性脂肪肝病、心血管疾病和癌症相关的疾病、紊乱或疾病。
• [EN] PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF<br/>[FR] COMPOSÉS ACTIVATEURS DE L'AMPK DE PHÉNANTHRÈNE, COMPOSITIONS, PROCÉDÉS ET UTILISATIONS DE CEUX-CI
  申请人：NESTLE SA

  公开号：WO2020229375A1

  公开（公告）日：2020-11-19

  The present invention relates to a compound having general formula I for use in the activation of AMPK. A composition comprising said compound for use in the activation of AMPK is also provided.

  本发明涉及一种具有通式I的化合物，用于激活AMPK。还提供了一种包含该化合物的组合物，用于激活AMPK。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20150225354A1

  公开（公告）日：2015-08-13

  A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

  提供一种具有肠肽酶抑制作用的融合杂环化合物以及将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。具体来说，提供一种由以下公式（I）表示的化合物：其中每个符号均如本文所定义，或其盐，并提供将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。