N'1,N'3-dimethyl-2-((morpholinoamino)methylene)-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide | 1183894-79-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N'1,N'3-dimethyl-2-((morpholinoamino)methylene)-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide
• 英文别名: 1-N',3-N'-bis(benzenecarbonothioyl)-1-N',3-N'-dimethyl-2-[(morpholin-4-ylamino)methylidene]propanedihydrazide
• CAS: 1183894-79-2
• 化学式: C₂₄H₂₈N₆O₃S₂
• 分子量: 512.657
• InChiKey: JQSHIVWEPSEIFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  153
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS<br/>[FR] COMPOSÉS DE TRAITEMENT DE TROUBLES PROLIFÉRATIFS
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2009105257A1

  公开（公告）日：2009-08-27

  Disclosed are compounds of Formula (I) and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.

  揭示了化合物的结构式(I)以及使用这些化合物治疗患有增殖性疾病（如癌症）的受试者的方法，以及用于治疗对Hsp70诱导和/或自然杀伤细胞诱导响应的疾病的方法。此外，还揭示了包含这些化合物和药用载体的药物组合物。
• COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS
  申请人：Kowalczyk-Prezewloka Teresa

  公开号：US20110294814A1

  公开（公告）日：2011-12-01

  Disclosed are compounds of Formula (I) and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
• US8581004B2
  申请人：——

  公开号：US8581004B2

  公开（公告）日：2013-11-12