3-[1-(2-phenyl-4-quinolyl)-4-piperidyl]-4H-1,2,4-triazole hydrochloride | 313053-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[1-(2-phenyl-4-quinolyl)-4-piperidyl]-4H-1,2,4-triazole hydrochloride
• 英文别名: 2-phenyl-4-[4-(1H-1,2,4-triazol-5-yl)piperidin-1-yl]quinoline;hydrochloride
• CAS: 313053-31-5
• 化学式: C₂₂H₂₁N₅*ClH
• 分子量: 391.903
• InChiKey: OKRQQDYYZUXRSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.83
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  57.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• US6297256B1
  申请人：——

  公开号：US6297256B1

  公开（公告）日：2001-10-02
• [EN] ARYL AND HETEROARYL SUBSTITUTED PYRIDINO DERIVATIVES; GABA BRAIN RECEPTOR LIGANDS<br/>[FR] DERIVES PYRIDINO SUBSTITUES ARYLE ET HETEROARYLE; LIGANDS DES RECEPTEURS CEREBRAUX GABA
  申请人：NEUROGEN CORP

  公开号：WO2000077008A2

  公开（公告）日：2000-12-21

  Disclosed are aryl and heteroaryl substituted pyridino compounds. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs an for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.