N',N'-diethyl-N-(5-methylquinolin-4-yl)propane-1,3-diamine | 848128-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N',N'-diethyl-N-(5-methylquinolin-4-yl)propane-1,3-diamine
• CAS: 848128-34-7
• 化学式: C₁₇H₂₅N₃
• 分子量: 271.406
• InChiKey: JXKZJIYKRHMCIQ-UHFFFAOYSA-N

物化性质

• 沸点：
  426.4±40.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.69
• 重原子数：
  20.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  28.16
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-氯-7-甲基喹啉 、 N',N'-diethyl-N-(5-methylquinolin-4-yl)propane-1,3-diamine 反应 2.0h， 生成 N',N'-diethyl-N-(7-methylquinolin-4-yl)propane-1,3-diamine
  参考文献：
  名称：

  Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

  摘要：

  A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.037
• 作为产物：
  描述：

  4-羟基-5-甲基喹啉 在 三氯氧磷 作用下， 反应 5.0h， 生成 N',N'-diethyl-N-(5-methylquinolin-4-yl)propane-1,3-diamine
  参考文献：
  名称：

  Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

  摘要：

  A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.037