3-methyl-3-benzoyl-2-butanol | 56010-60-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-3-benzoyl-2-butanol
• 英文别名: 3-Hydroxy-2,2-dimethyl-1-phenylbutan-1-one
• CAS: 56010-60-7
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: PKPITIVXTVOBAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-Methoxy-3,3,4-trimethyl-2-phenyl-oxetane 在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 生成 3-methyl-3-benzoyl-2-butanol
  参考文献：
  名称：

  Photochemical reactions of arenecarboxylic acid esters with electron-rich alkenes: 2 + 2 cycloaddition, hydrogen abstraction, and cycloreversion

  摘要：

  DOI：

  10.1021/jo00262a031

文献信息

• Preparation of Enolates from<i>α</i>-Haloketones with<i>n</i>-BuLi, PhMgBr, or Et₂Zn<i>via</i>Halogen-Metal Exchange Reaction
  作者：Yoshitaka Aoki、Koichiro Oshima、Kiitiro Utimoto

  DOI：10.1246/cl.1995.463

  日期：1995.6

  Metal-halogen exchange of α-iodoketones was performed upon treatment with n-BuLi, PhMgBr, Et2Zn or Me3Al in ether at 0 °C to give the corresponding metal enolates which reacted with aldehydes to provide the aldol type products in good yields.

  对α-碘酮进行金属-卤素交换反应，使用n-BuLi、PhMgBr、Et2Zn或Me3Al在0 °C的醚中处理，得到相应的金属烯醇盐，这些烯醇盐与醛反应，提供了良产率的醇类产品。
• 1,4-Carbonyl participation in solvolysis of alkyl toluene-p-sulphonates
  作者：Philip K. G. Hodgson、Stuart Warren

  DOI：10.1039/p29750000372

  日期：——

  2,2-Dimethyl-3-oxo-3-phenylpropyl toluene-p-sulphonate (tosylate) and some related 3-oxoalkyl tosylates are solvolysed in buffered carboxylic acid solvents by 1,4-carbonyl participation to give unrearranged carboxylate esters. The reactions are too fast to be direct displacements, and do not occur in similar compounds which lack the carbonyl group. Secondary alkyl tosylates in the same series also

  2，2-二甲基-3-氧代-3-苯基丙基甲苯对磺酸酯（甲苯磺酸酯）和一些相关的3-氧代烷基甲苯磺酸酯通过1，4-羰基参与溶剂化在缓冲的羧酸溶剂中，得到未重排的羧酸酯。该反应太快而不能直接取代，并且在缺少羰基的类似化合物中不会发生。同一系列的仲烷基甲苯磺酸盐也通过1,4-羰基参与反应，但发生中间阳离子片段，并与溶剂反应生成未重排的产物。
• Cement products and methods of making and using the same
  申请人：Pioneer Surgical Technology, Inc.

  公开号：US10413632B2

  公开（公告）日：2019-09-17

  Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

  所公开的是水泥产品、使用水泥产品形成水泥的方法以及在整形外科和牙科应用中使用水泥产品的方法。一般来说，所公开的水泥产品包括第一组分和第二组分。第一组分包括一种可聚合树脂，该树脂由乙烯不饱和双键、适当的缩水甘油基和/或适当的异氰酸酯基组成。第二组份包括一种由一种以上胺组成的化合物，这些胺选自由伯胺、仲胺、叔胺和季胺组成的组。或者，第二组份包括由合适的巯基（SH-）、受阻胺或二甲基硫代甲苯二胺（DMTDA）组成的化合物。可选地，骨水泥产品还包括填料和/或生物活性成分，以促进骨形成。
• Bioactive spinal implant material and method of manufacture thereof
  申请人：——

  公开号：US20030087984A1

  公开（公告）日：2003-05-08

  Bioactive spinal implant materials having optimized radiopacity, stiffness, and bioactivity properties for formulation of shaped bodies capable of withstanding large dynamic, compressive loads are provided. The invention also provides methods of making the optimized implant materials.

  本发明提供的生物活性脊柱植入材料具有优化的放射韧性、刚度和生物活性特性，用于配制能够承受大动态压缩载荷的异形体。本发明还提供了制造优化植入材料的方法。
• Bioactive spinal implants and method of manufacture thereof
  申请人：——

  公开号：US20030125739A1

  公开（公告）日：2003-07-03

  A bioactive spinal implant used in cervical fusion, Anterior Lumbar Interbody Fusion (ALIF), Posterior Lumbar Interbody Fusion (PLIF), and Transforaminal Interbody Fusion (TLIF), having properties and geometries that enhance bone contact, stability, and fusion between adjacent vertebral bodies.

  一种用于颈椎融合术、前路腰椎椎体间融合术（ALIF）、后路腰椎椎体间融合术（PLIF）和经椎间隙椎体间融合术（TLIF）的生物活性脊柱植入物，其特性和几何形状可增强相邻椎体之间的骨接触、稳定性和融合性。