3-硝基-苯并噻唑并(3,2-A)喹啉鎓氯化物 | 82773-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-硝基-苯并噻唑并(3,2-A)喹啉鎓氯化物
• 英文名称: 3-Nitrobenzothiazolo(3,2-a)quinolinium
• 英文别名: 3-nitro-[1,3]benzothiazolo[3,2-a]quinolin-12-ium
• CAS: 82773-09-9
• 化学式: C15H9N2O2S+
• 分子量: 281.31
• InChiKey: KZSSUNYIALKHLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition
  申请人：Sistema Universitario Ana G. Mendez, Inc.

  公开号：US20170079973A1

  公开（公告）日：2017-03-23

  Disclosed is the synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds. The compounds are further used as markers due to their fluorescent properties including in hypoxic environments. This disclosure further describes anti-cancer screening of two BQS, namely, 7-benzyl-3-aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303).

  本文披露了苯并咔唑[3,2-a]喹啉盐的合成过程，以及氯取代基、氨基取代基和硝基取代基的加入，从而产生多种化合物。由于它们在低氧环境中的荧光特性，这些化合物进一步被用作标记物。本披露还描述了两种BQS的抗癌筛选，即7-苄基-3-氨基苯并咔唑[3,2-a]喹啉盐（ABQ-48: NSC D-763307）和相应的7-苄基-3-硝基苯并咔唑[3,2-a]喹啉盐（NBQ 48: NSC D-763303）。
• METHOD FOR PRODUCING BENZAZOLOQUINOLIUM (BQS) SALTS AND USING THE BIOLOGICAL ACTIVITY OF THE COMPOSITION
  申请人：Sistema Universitario Ana G. Mendez, Inc.

  公开号：US20180008590A9

  公开（公告）日：2018-01-11

  Disclosed is the synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds. The compounds are further used as markers due to their fluorescent properties including in hypoxic environments. This disclosure further describes anti-cancer screening of two BQS, namely, 7-benzyl-3-aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303).
• US9889128B2
  申请人：——

  公开号：US9889128B2

  公开（公告）日：2018-02-13