3,3-dimethyl-6-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinoline | 1201684-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,3-dimethyl-6-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinoline
• 英文别名: 3,3-dimethyl-6-[4-(trifluoromethyl)phenyl]-2,4-dihydro-1H-quinoline
• CAS: 1201684-73-2
• 化学式: C₁₈H₁₈F₃N
• 分子量: 305.343
• InChiKey: HBXPQJLPJTWNCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-氟-4-溴苯磺酰氯 、 3,3-dimethyl-6-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinoline 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 54.0h， 生成 1-(4-bromo-3-fluoro-benzenesulfonyl)-3,3-dimethyl-6-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinoline
  参考文献：
  名称：

  [EN] ANNELATED N-HETEROCYCLIC SULFONAMIDES WITH OXADIAZOLONE HEADGROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
  [FR] SULFONAMIDES N-HÉTÉROCYCLIQUES ANNELÉS AVEC GROUPEMENT DE TÊTE OXADIAZOLONE, PROCÉDÉS POUR LEUR PRÉPARATION ET LEUR UTILISATION COMME MÉDICAMENTS

  摘要：

  含有噁二唑酮头基的环化N-杂环磺酰胺，其制备方法及其作为药物的用途。本发明涉及含有噁二唑酮头基的环化N-杂环磺酰胺及其生理上可接受的盐和生理功能衍生物，显示出PPARδ或PPARδ和PPARα激动剂活性。所描述的是具有化合物I的结构的化合物，其中基团如定义所述，以及其生理上可接受的盐和制备方法。这些化合物适用于治疗和/或预防脂肪酸代谢障碍和葡萄糖利用障碍以及胰岛素抵抗参与的疾病，以及中枢和外周神经系统的脱髓鞘和其他神经退行性疾病。

  公开号：

  WO2009149820A1

文献信息

• ANNELATED N-HETEROCYCLIC SULFONAMIDES WITH OXADIAZOLONE HEADGROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
  申请人：Keil Stefanie

  公开号：US20120122853A1

  公开（公告）日：2012-05-17

  Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals The invention relates to annelated N-heterocyclic sulfonamides with oxadiazolone headgroup and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARalpha agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

  本发明涉及具有氧代噻唑酮头基的环状N-杂环磺酰胺，以及它们的生理上可接受的盐和生理上功能衍生物，具有PPARδ或PPARδ和PPARα激动剂活性。所描述的是I式化合物，其中基团如定义所述，以及它们的生理上可接受的盐和制备过程。这些化合物适用于治疗和/或预防脂肪酸代谢障碍和葡萄糖利用障碍，以及胰岛素抵抗涉及的障碍和中枢和外周神经系统的脱髓鞘和其他神经退行性疾病。
• US8946212B2
  申请人：——

  公开号：US8946212B2

  公开（公告）日：2015-02-03
• [EN] ANNELATED N-HETEROCYCLIC SULFONAMIDES WITH OXADIAZOLONE HEADGROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS<br/>[FR] SULFONAMIDES N-HÉTÉROCYCLIQUES ANNELÉS AVEC GROUPEMENT DE TÊTE OXADIAZOLONE, PROCÉDÉS POUR LEUR PRÉPARATION ET LEUR UTILISATION COMME MÉDICAMENTS
  申请人：SANOFI AVENTIS

  公开号：WO2009149820A1

  公开（公告）日：2009-12-17

  Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals The invention relates to annelated N-heterocyclic sulfonamides with oxadiazolone headgroup and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARalpha agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

  含有噁二唑酮头基的环化N-杂环磺酰胺，其制备方法及其作为药物的用途。本发明涉及含有噁二唑酮头基的环化N-杂环磺酰胺及其生理上可接受的盐和生理功能衍生物，显示出PPARδ或PPARδ和PPARα激动剂活性。所描述的是具有化合物I的结构的化合物，其中基团如定义所述，以及其生理上可接受的盐和制备方法。这些化合物适用于治疗和/或预防脂肪酸代谢障碍和葡萄糖利用障碍以及胰岛素抵抗参与的疾病，以及中枢和外周神经系统的脱髓鞘和其他神经退行性疾病。