5-cyano-2-(quinolin-2-ylamino)pyridin-1-ium chloride | 1258453-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-cyano-2-(quinolin-2-ylamino)pyridin-1-ium chloride
• 英文别名: 6-(quinolin-2-ylamino)pyridin-1-ium-3-carbonitrile;chloride
• CAS: 1258453-34-7
• 化学式: C₁₅H₁₀N₄*ClH
• 分子量: 282.732
• InChiKey: YTYBSSXNNMYTMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.67
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA
  申请人：Tazi Jamal

  公开号：US20120329796A1

  公开（公告）日：2012-12-27

  The present invention relates to compound (I) wherein: means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a —CN group, a hydroxyl group, a —COOR 1 group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 3 )fluoroalkoxy group, a —NO2 group, a —NRiR2 group, a (C 1 -C 4 )alkoxy group, a phenoxy group and a (C 1 -C 3 )alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n′ is 1 or 2, R′ is a hydrogen atom, a halogen atom or a group chosen among a (Ci-C3)alkyl group, a hydroxyl group, a —COOR 1 group, a —NO2 group, a —NR 1 R 2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (Ci-C3)fluoroalkyl group, a (C 1 -C 4 )alkoxy group and a —CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating pathological or nonpathological conditions linked with premature aging. Some of said compounds are new and also form part of the invention.

  本发明涉及化合物(I)，其中：表示吡啶嗪、嘧啶或吡嗪基团，R独立地表示氢原子、卤素原子或在-CN基团、羟基基团、-COOR1基团、(C1-C3)氟烷基团、(C1-C3)氟烷氧基团、-NO2基团、-NRiR2基团、(C1-C4)烷氧基团、苯氧基团和(C1-C3)烷基团中选择的一种基团，所述烷基可以选择性地被一个羟基基团单取代，n为1、2或3，n'为1或2，R'为氢原子、卤素原子或在(Ci-C3)烷基团、羟基基团、-COOR1基团、- 基团、-NR1R2基团、吗啉基或吗啉基团、N-甲基哌嗪基团、(Ci-C3)氟烷基团、(C1-C4)烷氧基团和-CN基团中选择的一种基团，Z为N或C，Y为N或C，X为N或C，W为N或C，T为N或C，U为N或C，用作预防、抑制或治疗与早衰有关的病理或非病理状态的药剂。其中一些化合物是新的，也是本发明的一部分。
• Compounds useful for treating AIDS
  申请人：ABIVAX

  公开号：US10017498B2

  公开（公告）日：2018-07-10

  A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NR1R2 group, a (C1-C3)fluoroalkoxy group, a —NO2 group, a phenoxy group, or a (C1-C4)alkoxy group, R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group, R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, or a (C1-C4)alkoxy group, R″ is a hydrogen atom or a (C1-C4)alkyl group, n is 1, 2, or 3, and n′ is 1 or 2.

  具有下式的化合物或其药学上可接受的盐： 其中 R 独立地代表氢原子、卤素原子、(C1-C3)烷基、-NR1R2 基团、(C1-C3)氟烷氧基、-NO2 基团、苯氧基或 (C1-C4)烷氧基、 R1 和 R2 独立地为氢原子或 (C1-C3) 烷基、 R′ 是氢原子、卤素原子、(C1-C3)烷基或(C1-C4)烷氧基、 R″ 是氢原子或 (C1-C4) 烷基、 n 是 1、2 或 3，以及 n′ 为 1 或 2。
• Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
  申请人：ABIVAX

  公开号：US10253020B2

  公开（公告）日：2019-04-09

  The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3) alkyl group.

  式（Ia）化合物或其药学上可接受的盐的制造和使用，用于预防、抑制或治疗癌症、艾滋病和/或早衰。式 (Ia)化合物为： 其中 R 独立地代表氢原子、卤素原子、(C1-C3)烷基、-CN 基团、羟基、-COOR1 基团、(C1-C3)氟烷基、-NO2 基团、-NR1R2 基团或(C1-C3)烷氧基； R′ 是氢原子、卤素原子、(C1-C3)烷基、- 基团、(C1-C3)烷氧基或 -NR1R2 基团；以及 R1 和 R2 是氢原子或 (C1-C3) 烷基。
• Compounds for preventing, inhibiting, or treating cancer, aids and/or premature aging
  申请人：ABIVAX

  公开号：US10683284B2

  公开（公告）日：2020-06-16

  The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3) alkyl group.

  式（Ia）化合物或其药学上可接受的盐的制造和使用，用于预防、抑制或治疗癌症、艾滋病和/或早衰。式 (Ia)化合物为： 其中 R 独立地代表氢原子、卤素原子、(C1-C3)烷基、-CN 基团、羟基、-COOR1 基团、(C1-C3)氟烷基、-NO2 基团、-NR1R2 基团或(C1-C3)烷氧基； R′ 是氢原子、卤素原子、(C1-C3)烷基、- 基团、(C1-C3)烷氧基或 -NR1R2 基团；以及 R1 和 R2 是氢原子或 (C1-C3) 烷基。
• Compound, and production method thereof, and methods of treatment using the compound
  申请人：ABIVAX

  公开号：US10975063B2

  公开（公告）日：2021-04-13

  The manufacture of 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof, and use of 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof, for treating various conditions, and/or inhibiting replication of HIV-1 in a patient infected with HIV-1, by administering to a patient in need thereof an effective quantity of 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof.

  8-氯-N-[4-(三氟甲氧基)苯基]喹啉-2-胺或其药学上可接受的盐的制造，以及8-氯-N-[4-(三氟甲氧基)苯基]喹啉-2-胺或其药学上可接受的盐用于治疗各种疾病、和/或通过向有需要的患者施用有效量的 8-氯-N-[4-(三氟甲氧基)苯基]喹啉-2-胺或其药学上可接受的盐，抑制感染 HIV-1 的患者体内 HIV-1 的复制。