N,N-bis(quinolin-2-ylmethyl)quinolin-8-amine | 1613167-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N-bis(quinolin-2-ylmethyl)quinolin-8-amine
• CAS: 1613167-17-1
• 化学式: C₂₉H₂₂N₄
• 分子量: 426.52
• InChiKey: PKDXSOQPGHYOHS-UHFFFAOYSA-N

物化性质

• 沸点：
  638.3±55.0 °C(predicted)
• 密度：
  1.289±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.54
• 重原子数：
  33.0
• 可旋转键数：
  5.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.91
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N,N-bis(quinolin-2-ylmethyl)quinolin-8-amine 在 高氯酸 作用下， 以 乙醇 为溶剂， 以32.8%的产率得到
  参考文献：
  名称：

  Synthesis, characterization, and biological activities of two Cu(II) and Zn(II) complexes with one polyquinoline ligand

  摘要：

  Two new complexes, [CuLCl]ClO4 (1) and [Zn2L2SO4(H2O)(2)](ClO4)(2) (2) [L = N,N-bis(quinolin-2-ylmethyl) quinolin-8-amine], have been synthesized and structurally characterized. The interactions of two complexes with CT-DNA have been investigated by UV absorption, fluorescence spectroscopy, viscosity measurements and gel electrophoresis under physiological conditions. Results show that the complexes bind to CT-DNA with a moderate intercalative mode and exhibit efficient DNA cleavage activity on UV-A light of 365 nm. Furthermore, two complexes could quench the intrinsic fluorescence of BSA in a static quenching process based on BSA binding experiments. Notably, in vitro cytotoxicity study of two complexes on four human tumor cells lines (7404, HeLa, MCF-7, and HepG-2) indicate that both of them have the potential to act as effective anticancer drugs with low IC50 values. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.04.018
• 作为产物：
  描述：

  8-氨基喹啉 、 2-氯甲基喹啉盐酸盐 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 N,N-bis(quinolin-2-ylmethyl)quinolin-8-amine
  参考文献：
  名称：

  Synthesis, characterization, and biological activities of two Cu(II) and Zn(II) complexes with one polyquinoline ligand

  摘要：

  Two new complexes, [CuLCl]ClO4 (1) and [Zn2L2SO4(H2O)(2)](ClO4)(2) (2) [L = N,N-bis(quinolin-2-ylmethyl) quinolin-8-amine], have been synthesized and structurally characterized. The interactions of two complexes with CT-DNA have been investigated by UV absorption, fluorescence spectroscopy, viscosity measurements and gel electrophoresis under physiological conditions. Results show that the complexes bind to CT-DNA with a moderate intercalative mode and exhibit efficient DNA cleavage activity on UV-A light of 365 nm. Furthermore, two complexes could quench the intrinsic fluorescence of BSA in a static quenching process based on BSA binding experiments. Notably, in vitro cytotoxicity study of two complexes on four human tumor cells lines (7404, HeLa, MCF-7, and HepG-2) indicate that both of them have the potential to act as effective anticancer drugs with low IC50 values. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.04.018