4,4,5,5,6,6,7,7,7-Nonafluoro-1-phenylheptan-1-one | 606934-96-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,4,5,5,6,6,7,7,7-Nonafluoro-1-phenylheptan-1-one
• CAS: 606934-96-7
• 化学式: C₁₃H₉F₉O
• 分子量: 352.199
• InChiKey: OMWAQMPYTCTNRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4,4,5,5,6,6,7,7,7-Nonafluoro-1-phenylheptan-1-one 在 硼烷四氢呋喃络合物 、 (R)-2-甲基-CBS-恶唑硼烷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 0.25h， 生成 4,4,5,5,6,6,7,7,7-nonafluoro-1-phenyl-heptan-1-ol 、 4,4,5,5,6,6,7,7,7-nonafluoro-1-phenyl-heptan-1-ol
  参考文献：
  名称：

  Enantiomeric resolution of fluorous mixture by chiral CD columns: asymmetric reduction of a mixture of fluorous ketones

  摘要：

  Asymmetric reduction of a mixture of four fluorous ketone analogues was carried out with (R)-oxazaborolidine as a catalyst. The fluorous mixture products were resolved by a reverse phase HPLC with chiral beta-cyclodextrin column to result in good separation of the enantiomers. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01539-9
• 作为产物：
  描述：

  4,4,5,5,6,6,7,7,7-Nonafluoro-1-phenylheptan-1-ol 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到4,4,5,5,6,6,7,7,7-Nonafluoro-1-phenylheptan-1-one
  参考文献：
  名称：

  Enantiomeric resolution of fluorous mixture by chiral CD columns: asymmetric reduction of a mixture of fluorous ketones

  摘要：

  Asymmetric reduction of a mixture of four fluorous ketone analogues was carried out with (R)-oxazaborolidine as a catalyst. The fluorous mixture products were resolved by a reverse phase HPLC with chiral beta-cyclodextrin column to result in good separation of the enantiomers. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01539-9

文献信息

• Hydroperfluoroalkylation of electron-deficient olefins with perfluoroalkyl iodides promoted by zinc/viologen
  作者：Sheng-Hua Zhou、Jin-Hong Lin、Gang Zhao、Ji-Chang Xiao、Wei-Guo Cao

  DOI：10.1039/c6ra11557h

  日期：——

  The hydroperfluoroalkylation of electron-deficient olefins with perfluoroalkyl iodides promoted by a zinc/viologen system is described. Interestingly, no iodoperfluoroalkylation product was observed without the presence of radical H-donor.

  描述了由锌/紫罗兰体系促进的电子不足的烯烃与全氟烷基碘的加氢全氟烷基化。有趣的是，在不存在自由基H-给体的情况下，未观察到碘全氟烷基化产物。