cyclohexane-1r,2c,3c,4c-tetraol | 199013-92-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclohexane-1r,2c,3c,4c-tetraol
• 英文别名: Cyclohexan-1r,2c,3c,4c-tetraol；Cyclohexantetrol-(1r,2c,3c,4c)；(1R,2R,3S,4S)-cyclohexane-1,2,3,4-tetrol
• CAS: 199013-92-8
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: WESBWDZFWNIVRV-FBXFSONDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cyclohexane-1r,2c,3c,4c-tetraol 、 苯甲酰氯 生成 1r,2c,3c,4c-tetrakis-benzoyloxy-cyclohexane
  参考文献：
  名称：

  Criegee; Becher, Chemische Berichte, 1957, vol. 90, p. 2516,2520

  摘要：

  DOI：
• 作为产物：
  描述：

  (-)-(1S,2S,3R,4R)-3,4-(cyclohexylidenedioxy)-2-methoxycyclohexan-1-ol 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到cyclohexane-1r,2c,3c,4c-tetraol
  参考文献：
  名称：

  酮同化生成α-甲氧基酮：在conduritol合成中的应用

  摘要：

  Trost将酮转化为α-甲氧基化的高级同系物的砜同系物方法的范围已大大扩展。在羟基砜重排步骤中使用四氯化锆（或ha）可得到芳烷基酮，二烷基酮和环烷酮的加合物，收率良好，并且重排发生时具有全部区域选择性。提出了机械观察，其解释了作为副产物的α-羟基醛的形成，并且表明了制备它们的有效方法。描述了同源方法在二氢conduritols的立体选择性合成中的应用。

  DOI：

  10.1039/a703073h

文献信息

• Inositol compounds and uses of same in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence
  申请人：Cruz Antonio

  公开号：US20070111970A1

  公开（公告）日：2007-05-17

  Inositol derivatives are described that are represented by the structural formula I wherein X is a radical of scyllo-inositol wherein one or more of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are independently alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfoxide, sulfate, sulfonyl, sulfenyl, sulfonate, sulfinyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, seleno, silyl, silyloxy, silylthio, carboxyl, carbonyl, carbamoyl, or carboxamide and the other of R 1 , R 2 , R 3 , R 4 , R 5 , or R 6 are hydroxyl, or pharmaceutically acceptable salts thereof. The compounds, compositions comprising same and methods using same are described for use in the prevention and/or treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence.
• SCREENING METHODS FOR AMYLOID BETA MODULATORS
  申请人：Slon-Usakiewicz Jacek

  公开号：US20110028719A1

  公开（公告）日：2011-02-03

  The present invention relates to methods for screening, identifying, and/or quantifying modulators of amyloid and/or aggregates, fibrils or components thereof, in particular modulators of amyloid β-peptide (Aβ) or Aβ fibrils. Aspects of the invention provide methods for screening putative modulators against an Amyloid target, in particular an Aβ target, so as to determine which modulators bind to or interact with the target, or interfere with the interaction of an indicator agent and the target. Particular aspects of the invention employ mass spectrometric methods for the screening of an Amyloid target against compound libraries, in particular mixtures of compounds or combinatorial libraries.