N'-[2-[(3-amino-4-methylpyridin-2-yl)amino]-8-chloro-5-quinolinyl]N,N-dimethylsulfamide | 1381954-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N'-[2-[(3-amino-4-methylpyridin-2-yl)amino]-8-chloro-5-quinolinyl]N,N-dimethylsulfamide
• 英文别名: 2-[(3-Amino-4-methylpyridin-2-yl)amino]-8-chloro-5-(dimethylsulfamoylamino)quinoline
• CAS: 1381954-39-7
• 化学式: C₁₇H₁₉ClN₆O₂S
• 分子量: 406.896
• InChiKey: STCNAZVMTAVEOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Compounds useful for treating AIDS
  申请人：Société Splicos

  公开号：EP2465502A1

  公开（公告）日：2012-06-20

  The present invention relates to compound (I) for use as an agent for preventing, inhibiting or treating AIDS. The present invention further relates to compounds of formula (I) wherein X is CR0 or N; R0, R1, R2, R3, R4, R7 and R8 independently represent a hydrogen atom, a halogen atom or a group chosen among a (C1-C5)alkyl group, a (C3-C6)cycloalkyl group, a (C1-C5)fluoroalkyl group, a (C1-C5)alkoxy group, a (C1-C5)fluoroalkoxy group, a -CN group, a -COORa group, a -NO2 group, a -NRaRb group, a -NRa-SO2-NRaRb group, a -NRa-SO2-Ra group, a -NRa-C(=O)-Ra group, a -NRa-C(=O)-NRaRb group, a -SO2-NRaRb group, a -SO3H group, a -OH group, a -O-SO2-ORc group, a -O-P(=O)-(ORc)(ORd) group, a -O-CH2-COORc group and can further be a group chosen among: R5 represents a hydrogen atom, a (C1-C5)alkyl group or a (C3-C6)cycloalkyl group; R10 is a hydrogen atom or a chlorine atom, and R11 is a hydrogen atom or a (C1-C4)alkyl group or anyone of its pharmaceutically acceptable salts.

  本发明涉及用于防止、抑制或治疗艾滋病的化合物（I）。本发明进一步涉及公式（I）的化合物，其中X是CR0或N；R0、R1、R2、R3、R4、R7和R8独立地代表一个氢原子、一个卤素原子或一个选自（C1-C5）烷基团、（C3-C6）环烷基团、（C1-C5）氟烷基团、（C1-C5）烷氧基团、（C1-C5）氟烷氧基团、-CN基团、-COORa基团、-NO2基团、-NRaRb基团、-NRa-SO2-NRaRb基团、-NRa-SO2-Ra基团、-NRa-C(=O)-Ra基团、-NRa-C(=O)-NRaRb基团、-SO2-NRaRb基团、-SO3H基团、-OH基团、-O-SO2-ORc基团、-O-P(=O)-(ORc)(ORd)基团、-O-CH2-COORc基团，并且还可以是一个选自：R5代表一个氢原子、一个（C1-C5）烷基团或一个（C3-C6）环烷基团；R10是一个氢原子或一个氯原子，R11是一个氢原子或一个（C1-C4）烷基团或其药用可接受盐的任何一个。
• COMPOUNDS USEFUL FOR TREATING AIDS
  申请人：ABIVAX

  公开号：EP2651416B1

  公开（公告）日：2018-05-09
• QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF INFLAMMATION DISEASES
  申请人：ABIVAX

  公开号：US20220023324A1

  公开（公告）日：2022-01-27

  A compound of Formula (I): or anyone of its metabolites or a pharmaceutically acceptable salt thereof, for use for treating and/or preventing an inflammatory disease, disorder or condition, wherein each R is independently hydrogen, halogen, —CN, hydroxyl, (C 1 -C 3 )fluoroalkyl, (C 1 -C 3 )fluoroalkoxy, (C 3 -C 6 )cycloalkyl, —NO 2 , —NR 1 R 2 , (C 1 -C 4 )alkoxy, phenoxy, —NR 1 —SO 2 —NR 1 R 2 , —NR 1 —SO 2 —R1, —NR 1 —C(═O)—R 1 , —NR 1 —C(═O)—NR 1 R 2 , —SO 2 —NR 1 R 2 , —SO 3 H, —O—SO 2 —OR 3 , —O—P(═O)—(OR 3 )(OR 4 ), —O—CH 2 —COOR 3 , (C 1 -C 3 )alkyl; each R′ is independently hydrogen, (C1-C3)alkyl, hydroxyl, halogen, —NO 2 , —NR 1 R 2 , morpholinyl, morpholino, N-methylpiperazinyl, (C 1 -C 3 )fluoroalkyl, (C 1 -C 4 )alkoxy, —O—P(═O)—(OR 3 )(OR 4 ), —CN, a —NH—SO 2 —N(CH 3 ) 2 group, or other groups and further relates to A compound of formula (IV): or a pharmaceutically acceptable salt thereof, for use for treating and/or preventing an inflammatory disease, disorder or condition, wherein V, Z, R, R′, n, and n′ are as described above.
• BIOMARKERS, AND USES IN TREATMENT OF VIRAL INFECTIONS, INFLAMMATIONS, OR CANCER
  申请人：ABIVAX

  公开号：US20220145406A1

  公开（公告）日：2022-05-12

  Biomarkers and uses thereof in monitoring, assessing, and/or treatment of viral infections, or inflammatory diseases, disorders, or conditions, or cancer.
• US9061999B2
  申请人：——

  公开号：US9061999B2

  公开（公告）日：2015-06-23