N-benzyl-N'-2-(4-phenylthiazolyl)thiourea | 135211-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-benzyl-N'-2-(4-phenylthiazolyl)thiourea
• 英文别名: 1-Benzyl-3-(4-phenyl-1,3-thiazol-2-yl)thiourea
• CAS: 135211-01-7
• 化学式: C₁₇H₁₅N₃S₂
• 分子量: 325.458
• InChiKey: VOXLEMIFBOSVHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-benzyl-N'-2-(4-phenylthiazolyl)thiourea 在 lead(II) oxide 、 一水合肼 作用下， 以 乙醇 为溶剂， 以60%的产率得到1-Amino-2-benzyl-3-(4-phenyl-1,3-thiazol-2-yl)guanidine
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines

  摘要：

  The synthesis of fifteen new 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines is described. They were screened for their antimicrobial susceptibility by the standard disc diffusion method of the World Health Organization (WHO) and the activities compared with that of standard strain of Escherichia coli NCTC 10418. The sensitive aminoguanidines were further subjected to the minimum inhibitory concentration (MIC) test. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00032-x
• 作为产物：
  描述：

  2-氨基-4-苯基噻唑 、 异硫氰酸苯甲酯 以 苯 为溶剂， 生成 N-benzyl-N'-2-(4-phenylthiazolyl)thiourea
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines

  摘要：

  The synthesis of fifteen new 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines is described. They were screened for their antimicrobial susceptibility by the standard disc diffusion method of the World Health Organization (WHO) and the activities compared with that of standard strain of Escherichia coli NCTC 10418. The sensitive aminoguanidines were further subjected to the minimum inhibitory concentration (MIC) test. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00032-x

文献信息

• Madan; Taneja; Kudesia, Journal of the Indian Chemical Society, 1990, vol. 67, # 10, p. 809 - 811
  作者：Madan、Taneja、Kudesia

  DOI：——

  日期：——
• Madan; Taneja; Kudesia, Journal of the Indian Chemical Society, 1991, vol. 68, # 8, p. 471 - 472
  作者：Madan、Taneja、Kudesia

  DOI：——

  日期：——