methyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
• 化学式: C₂₆H₂₆FNO₄
• 分子量: 435.5
• InChiKey: RJYASJYIIVRJNV-WOJBJXKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Process for Preparing Pitavastatin, Intermediates and Pharmaceuctically Acceptable Salts Thereof
  申请人：Satyanarayana Reddy Manne

  公开号：US20120016129A1

  公开（公告）日：2012-01-19

  Processes for preparing pravastatin, intermediates and pharmaceutically acceptable salts thereof are provided Crystalline forms of pravastatin, intermediates and pharmaceutically acceptable salts thereof are also disclosed.

  提供了制备普伐他汀、中间体和药用可接受盐的工艺。还公开了普伐他汀、中间体和药用可接受盐的结晶形式。
• IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-Ý2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL¨-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
  申请人：MSN Laboratories Limited

  公开号：EP2387561A2

  公开（公告）日：2011-11-23
• US8487105B2
  申请人：——

  公开号：US8487105B2

  公开（公告）日：2013-07-16
• [EN] IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE (3R,5S)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL) QUINOLIN-3-YL]-3,5-DIHYDROXY-6(E)-HEPTENOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF<br/>[FR] PROCÉDÉ AMÉLIORÉ D'ÉLABORATION D'ACIDE (3R,5S)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHÉNYL)QUINOLIN-3-YL]-3,5-DIHYDROXY-6(E)-HEPTÈNOÏQUE DE HAUTE PURETÉ, Y COMPRIS SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
  申请人：MSN LAB LTD

  公开号：WO2010089770A2

  公开（公告）日：2010-08-12

  Processes for preparing pravastatin, intermediates and pharmaceutically acceptable salts thereof are provided Crystalline forms of pravastatin, intermediates and pharmaceutically acceptable salts thereof are also disclosed.