(diethylamino)(4-phenylthiazol-2-ylamino)(acetyl)phosphine P-oxide | 934363-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (diethylamino)(4-phenylthiazol-2-ylamino)(acetyl)phosphine P-oxide
• 英文别名: N,N-diethyl-N'-(4-phenylthiazol-2-yl)-P-(acetyl)phosphonic diamide
• CAS: 934363-32-3
• 化学式: C₁₅H₂₀N₃O₂PS
• 分子量: 337.382
• InChiKey: FIPXFIIVOGZHPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.3
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (diethylamino)(4-phenylthiazol-2-ylamino)(acetyl)phosphine P-oxide 、 硫脲 在 碘 作用下， 以78%的产率得到
  参考文献：
  名称：

  New synthetic approach to phosphorylated 2-aminothiazoles

  摘要：

  DOI：

  10.1134/s1070363207020211
• 作为产物：
  描述：

  2-氨基-4-苯基噻唑 以 乙酸乙酯 、 苯 为溶剂， 生成 (diethylamino)(4-phenylthiazol-2-ylamino)(acetyl)phosphine P-oxide
  参考文献：
  名称：

  Reactions of tert-butyl N,N-diethyl-N′-(4-phenylthiazol-2-yl)-phosphorodiamidite with electrophilic reagents

  摘要：

  Previously unknown amidophosphorous acid derivatives were prepared by transamidation of tert-butyl N,N-diethyl-N'-(4-phenylthiazolyl)phosphorodiamidite with 2-amino-4-phenylthiazole, and their reactions with acetyl and benzoyl chloride were studied. These reactions are shown to proceed regioselectively according to the Arbuzov scheme to give the corresponding ketophosphonates. The reaction of the phosphorodiamidite with acetyl chloride in a I : 2 molar ratio involves formation of acetophosphonate that reacts in the enol form to give the corresponding (1-acetoxy)vinylphosphonate.

  DOI：

  10.1134/s1070363206090076

文献信息

• Glycidol esters from diethylamido-(4-phenylthiazolyl-2-amido)-ketophosphonates and their chemical modification
  作者：L. K. Sal’keeva、E. V. Minayeva、M. T. Nurmaganbetova、B. Z. Kokzhalova、A. I. Mantel’

  DOI：10.1134/s1070363209040136

  日期：2009.4

  Thiazolyl-containing esters of alpha-ketophosphonic acids (KPE) unknown earlier were synthesized and investigated in Darzens-Claisen reaction. Reactions were demonstrated to proceed by a classic scheme to form the corresponding phosphorylated glycidol esters whose alkaline hydrolysis gave rise to phosphorylated aldehydes of interesting nature.
• Synthesis and complex-forming properties of thiazolyl-containing organophosphorus complexone
  作者：Sh. K. Amerkhanova、L. K. Sal’keeva、R. M. Shlyapov、E. V. Minaeva、A. S. Uali

  DOI：10.1134/s1070363210060253

  日期：2010.6

  Alkaline hydrolysis of the previously prepared ethyl 2-methyl-2-[diethylamido-N-(4'-phenylthiazolyl-2-amido)phosphono]glycidate and 2-phenyl-2-[diethylamido-N-(4-phenylthiazolyl-2-amido)phosphono]glycidate accompanied by decarboxylation in situ of the obtained glycidic acids furnished 2-[diethylamido-(4'-phenylthiazolyl-2'-amido)phosphono]propionic and 2-phenyl-2-[diethylamido-(4'-phenylthiazolyl-2'-amido)phosphono]acetic aldehydes. The qualitative and quantitative evaluation of complex-forming ability of the compounds obtained with respect to transition metal ions was carried out. For identification of copper complex the evaluation of the stability constants of copper, cobalt, nickel, and zinc complexes was performed. Thermodynamic parameters of complex formation reactions were calculated. Correlation dependences between the physicochemical properties of metal ions and thermodynamic characteristics of complex formation with the organophosphorus ligands obtained were established.