6-{4-(4-fluorophenyl)-2-methyl-5-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2,5-dihydro-1H-pyrrol-3-yl}-2H-1,4-benzoxazin-3(4H)-one | 1454580-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 6-{4-(4-fluorophenyl)-2-methyl-5-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2,5-dihydro-1H-pyrrol-3-yl}-2H-1,4-benzoxazin-3(4H)-one
• CAS: 1454580-44-9
• 化学式: C₂₆H₂₇FN₂O₅
• 分子量: 466.509
• InChiKey: SNRBQUHXSGKXHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.84
• 重原子数：
  34.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.1
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  6-{4-(4-fluorophenyl)-2-methyl-5-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2,5-dihydro-1H-pyrrol-3-yl}-2H-1,4-benzoxazin-3(4H)-one 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以61%的产率得到6-[4-(4-fluorophenyl)-1-(2-hydroxyethyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

  摘要：

  Dihydrofuran-2-one and dihydropyrrol-2-one derivatives were identified as novel, potent and selective mineralocorticoid receptor (MR) antagonists by the structure-based drug design approach utilizing the crystal structure of MR/compound complex. Introduction of lipophilic substituents directed toward the unfilled spaces of the MR and identification of a new scaffold, dihydropyrrol-2-one ring, led to potent in vitro activity. Among the synthesized compounds, dihydropyrrol-2-one 11i showed an excellent in vitro activity (MR binding IC50 = 43 nM) and high selectivity over closely related steroid receptors such as the androgen receptor (AR), progesterone receptor (PR) and glucocorticoid receptor (GR) (>200-fold for AR and PR, 100-fold for GR). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.043
• 作为产物：
  描述：

  2-((tetrahydro-2H-pyran-2-yl)oxy)ethanamine 在 potassium tert-butylate 作用下， 以 四氢呋喃 、 水 、 叔丁醇 为溶剂， 反应 12.0h， 生成 6-{4-(4-fluorophenyl)-2-methyl-5-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2,5-dihydro-1H-pyrrol-3-yl}-2H-1,4-benzoxazin-3(4H)-one
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

  摘要：

  Dihydrofuran-2-one and dihydropyrrol-2-one derivatives were identified as novel, potent and selective mineralocorticoid receptor (MR) antagonists by the structure-based drug design approach utilizing the crystal structure of MR/compound complex. Introduction of lipophilic substituents directed toward the unfilled spaces of the MR and identification of a new scaffold, dihydropyrrol-2-one ring, led to potent in vitro activity. Among the synthesized compounds, dihydropyrrol-2-one 11i showed an excellent in vitro activity (MR binding IC50 = 43 nM) and high selectivity over closely related steroid receptors such as the androgen receptor (AR), progesterone receptor (PR) and glucocorticoid receptor (GR) (>200-fold for AR and PR, 100-fold for GR). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.043