| 1044566-37-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1044566-37-1
• 化学式: C₆H₁₅N*C₂₂H₂₇O₁₀P
• 分子量: 583.616
• InChiKey: IQZZVIGEVCFOGD-IBBSBOODSA-N

反应信息

• 作为产物：
  描述：

  在 溶剂黄146 作用下， 以 水 为溶剂， 反应 1.0h， 以57%的产率得到
  参考文献：
  名称：

  Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8

  摘要：

  A series of O2 and O3-derivatized methyl beta-D-talopyranosides were synthesized and evaluated in vitro as inhibitors of the galactose-binding galectin-1, -2, -3, -4 ( N- and C-terminal domains), 8 ( N- terminal domain), and 9 ( N- terminal domain). Galectin-4C and 8N were found to prefer the D-talopyranose configuration to the natural ligand D-galactopyranose configuration. Derivatization at talose O2 and/or O3 provided selective submillimolar inhibitors for these two galectins. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.066