8-(4-(4-amino-2-chlorophenoxy)-1-methylbutoxy)quinolin-2-amine | 635756-47-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(4-(4-amino-2-chlorophenoxy)-1-methylbutoxy)quinolin-2-amine
• 英文别名: 8-[5-(4-Amino-2-chlorophenoxy)pentan-2-yloxy]quinolin-2-amine
• CAS: 635756-47-7
• 化学式: C₂₀H₂₂ClN₃O₂
• 分子量: 371.867
• InChiKey: SKGPQIGPVPYWRM-UHFFFAOYSA-N

物化性质

• 沸点：
  606.2±55.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  83.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] 2-AMINOQUINOLINES AS MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS<br/>[FR] 2-AMINOQUINOLINES SERVANT D'ANTAGONISTES DE RECEPTEUR DE L'HORMONE DE CONCENTRATION DE MELANINE
  申请人：ABBOTT LAB

  公开号：WO2003105850A1

  公开（公告）日：2003-12-24

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

  本发明涉及公式(I)的化合物，或其治疗上适用的盐或前药，这些化合物通过黑素浓集激素受体拮抗黑素浓集激素（MCH）的效果，并且用于预防或治疗进食障碍、体重增加和肥胖。
• 2-Aminoquinolines as melanin concentrating hormone receptor antagonists
  申请人：——

  公开号：US20040063756A1

  公开（公告）日：2004-04-01

  The present invention is related to compounds of formula (I), 1 or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

  本发明涉及式(I)的化合物，或其治疗上适宜的盐或前药，通过黑素浓集激素受体拮抗黑素浓集激素（MCH）的作用，并且对于预防或治疗进食障碍、体重增加和肥胖症是有用的。
• Dyeing composition comprising a cationic tertiary para-phenylenediamine and a monosaccharide or disaccharide, processes and uses
  申请人：L'OREAL

  公开号：US20040221400A1

  公开（公告）日：2004-11-11

  The present application relates to a composition for the dyeing of keratin fibres, particularly human keratin fibres such as hair, comprising, in an appropriate dyeing medium, at least one cationic tertiary paraphenylenediamine containing a pyrrolidine ring, and at least one particular carbohydrate selected from monosaccharides, disaccharides and mixtures thereof. The invention further relates to the dyeing process in which this composition is used.

  本申请涉及一种用于染色角蛋白纤维的组合物，特别是用于染发等人类角蛋白纤维。该组合物包含至少一种含有吡咯烷环的阳离子三苯二胺和至少一种特定的单糖、双糖或其混合物，在适当的染料介质中。本发明还涉及使用该组合物的染色过程。
• US6989392B2
  申请人：——

  公开号：US6989392B2

  公开（公告）日：2006-01-24