2,3,6-trimethylhept-4(E)-ene-2-ol | 108643-14-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3,6-trimethylhept-4(E)-ene-2-ol
• 英文别名: (E)-2,3,6-trimethylhept-4-en-2-ol
• CAS: 108643-14-7
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: BDNGDAKTLOMPIW-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-1-(1'-Hydroxy-2'-methylpropyl)-2,2,3-trimethylcyclopropane 在 高氯酸 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 以83%的产率得到2,3,6-trimethylhept-4(E)-ene-2-ol
  参考文献：
  名称：

  Moiseenkov, Alexander M.; Czeskis, Boris A., Collection of Czechoslovak Chemical Communications, 1986, vol. 51, # 6, p. 1316 - 1322

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCTION OF 1-HYDROXY-19-NORCYCLOVITAMIN D DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION
  申请人：MERCIAN CORPORATION

  公开号：EP2085380A1

  公开（公告）日：2009-08-05

  A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.

  从25-羟基维生素D产生的一种环维生素D衍生物与四氧化锇或高锰酸盐反应，生成一个10,19-二醇环维生素D衍生物。这个10,19-二醇环维生素D衍生物与一种全卤酸盐或醋酸四酯铅反应，产生一个10-氧代环维生素D衍生物。通过一个环维生素D衍生物和一个1,10-烯基环维生素D衍生物，从10-氧代环维生素D衍生物产生一个1-羟基环维生素D衍生物。将1-羟基环维生素D衍生物进行溶剂解离，从而产生一个1-羟基-19-去维生素D衍生物。因此，提供了一种用于生产可用作1-羟基-19-去环维生素D衍生物合成中间体的新工艺，该中间体可用作一种制药剂；以及用于生产的中间体。
• 3-DESOXY-2-METHYLENE-19-NOR-VITAMIN D ANALOGS AND THEIR USES
  申请人：Wisconsin Alumni Research Foundation

  公开号：EP2721004B1

  公开（公告）日：2017-07-26
• 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES
  申请人：Wisconsin Alumni Research Foundation

  公开号：EP2768804B1

  公开（公告）日：2018-02-28
• 25-OH VITAMIN D DERIVATE ZUR BESTIMMUNG VON VITAMIN D METABOLITEN
  申请人：Orgentec Diagnostika GmbH

  公开号：EP3030243B1

  公开（公告）日：2017-07-26
• 25-OH VITAMIN D DERIVATIVES FOR DETERMINING VITAMIN D METABOLITES
  申请人：ORGENTEC DIAGNOSTIKA GMBH

  公开号：US20160195556A1

  公开（公告）日：2016-07-07

  The present invention relates to new vitamin D compounds which are bonded to a labelling group at the C3 stereocentre by means of a linker. The present invention further relates to a method for producing these vitamin D compounds and to the use of an intermediate for producing these compounds. The present invention also relates to a method for quantitatively determining vitamin D using a vitamin D compound according to the invention as a tracer. Furthermore, the present invention relates to a reagent for determining vitamin D, containing a compound according to the invention, and to the use thereof for determining vitamin D.