N-Isopropyl-1,2,3,4-tetrahydrochinaldin | 93759-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-Isopropyl-1,2,3,4-tetrahydrochinaldin
• 英文别名: 2-methyl-1-propan-2-yl-3,4-dihydro-2H-quinoline
• CAS: 93759-21-8
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: MAGSEJACEHVVHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• CASPASE INHIBITOR PRODRUGS
  申请人：Durrant Steven

  公开号：US20110137037A1

  公开（公告）日：2011-06-09

  This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors. This invention also relates to the processes for preparing these prodrugs of caspase inhibitors. This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.
• DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
  申请人：GILEAD SCIENCES, INC.

  公开号：US20220324866A1

  公开（公告）日：2022-10-13

  The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
• US8168798B2
  申请人：——

  公开号：US8168798B2

  公开（公告）日：2012-05-01