7,7-dimethyl-5-oxo-2-(4-hydroxy-6-methyl-2-oxo-2H-1-pyran-3-yl)-5,6,7,8-tetrahydroquinoline | 1401620-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7,7-dimethyl-5-oxo-2-(4-hydroxy-6-methyl-2-oxo-2H-1-pyran-3-yl)-5,6,7,8-tetrahydroquinoline
• 英文别名: 2-(4-Hydroxy-6-methyl-2-oxopyran-3-yl)-7,7-dimethyl-6,8-dihydroquinolin-5-one
• CAS: 1401620-84-5
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: XODFFYIPNNQHEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  去氢乙酸 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 生成 7,7-dimethyl-5-oxo-2-(4-hydroxy-6-methyl-2-oxo-2H-1-pyran-3-yl)-5,6,7,8-tetrahydroquinoline
  参考文献：
  名称：

  Silica supported sodium hydrogen sulfate (NaHSO4–SiO2): A novel, green catalyst for synthesis of pyrazole and pyranyl pyridine derivatives under solvent-free condition via heterocyclic β-enaminones

  摘要：

  NaHSO4-SiO2 is used as an efficient, mild and reusable catalyst for the synthesis of novel heterocyclic pyrazole (5a-h) and pyranyl pyridine (7a-h) derivatives via heterocyclic beta-enaminones (3a-d) under thermal solvent-free conditions. The remarkable features of this green, new methodology are high conversions, cleaner reaction profile, simple experimental and work-up procedures. Structures of the newly synthesized compounds have been elucidated on the basis of elemental analysis and spectral data (IR, H-1 NMR, C-13 NMR and mass spectrometry). The catalyst is characterized for the first time by using scanning electron microscopy-energy dispersive X-ray (SEM-EDX) and powder XRD. The catalyst can be reused several times without significant loss of its catalytic activity. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.07.024

文献信息

• Highly efficient solvent-free synthesis of novel pyranyl pyridine derivatives via β-enaminones using ZnO nanoparticles
  作者：Zeba N. Siddiqui、Nayeem Ahmed、Farheen Farooq、Kulsum Khan

  DOI：10.1016/j.tetlet.2013.04.072

  日期：2013.7

  Highly efficient ZnO nanoparticle catalyzed one-pot solvent-free synthesis of novel pyridine derivatives by three-component reaction of β-enaminones, different active methylene compounds, and ammonium acetate via Michael addition, cyclodehydration, and elimination sequence is reported. The catalyst was recyclable up to six catalytic cycles without a significant loss in the catalytic activity. This

  据报道，高效的ZnO纳米颗粒通过迈克尔-加成反应，β-烯胺酮，不同活性亚甲基化合物和乙酸铵的三组分反应，一环脱水和消除顺序，可以一锅无溶剂地合成新型吡啶衍生物。该催化剂可循环使用多达六个催化循环，而催化活性没有明显损失。该新方案具有环境友好，产率高，无溶剂，催化剂载量低，反应时间短和操作程序方便的优点。通过XRD，SEM和TEM分析对ZnO纳米颗粒进行了表征。