(5R,7R,8S,9R)-8,9-dibenzyloxy-7-benzyloxymethyl-1-tert-butoxycarbonyl-3,6-dioxa-2-thia-1-azaspiro[4.4]nonane-2,2-dioxide | 1192412-25-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5R,7R,8S,9R)-8,9-dibenzyloxy-7-benzyloxymethyl-1-tert-butoxycarbonyl-3,6-dioxa-2-thia-1-azaspiro[4.4]nonane-2,2-dioxide
• CAS: 1192412-25-1
• 化学式: C₃₂H₃₇NO₉S
• 分子量: 611.713
• InChiKey: CGPMQFQDUSOLHF-YZALVSPHSA-N

反应信息

• 作为产物：
  描述：

  (3S,4R,5R)-2-(hydroxymethyl)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-ol 、 tert-butyl (N-triethylammonium sulfonyl)carbamate 以 四氢呋喃 为溶剂， 以42%的产率得到(5S,7R,8S,9R)-8,9-dibenzyloxy-7-benzyloxymethyl-1-tert-butoxycarbonyl-3,6-dioxa-2-thia-1-azaspiro[4.4]nonane-2,2-dioxide
  参考文献：
  名称：

  Regioselective synthesis and biological evaluation of spiro-sulfamidate glycosides from exo-glycals

  摘要：

  We report the synthesis of spiro-sulfamidate glycosides from exo-glycals. This route is regioselective and furnishes an original class of spiro-hydantoin glycoside analogues. A biological evaluation of this family on a range of glycosidases shows that these compounds are weak but very selective inhibitors of a-glucosidase and amyloglucosidase. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.012