N'-[1-(2-hydroxyphenyl)ethylidene]-1H-indole-3-carbohydrazide | 1341213-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N'-[1-(2-hydroxyphenyl)ethylidene]-1H-indole-3-carbohydrazide
• CAS: 1341213-01-1
• 化学式: C₁₈H₁₇N₃O₂
• 分子量: 307.352
• InChiKey: LMRGNZLNDOALFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  77.48
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N'-[1-(2-hydroxyphenyl)ethylidene]-1H-indole-3-carbohydrazide 在 lead(IV) tetraacetate 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes

  摘要：

  First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spiro-cyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.077
• 作为产物：
  描述：

  3-吲哚乙酸 在 氯化亚砜 、 一水合肼 作用下， 以 乙醇 为溶剂， 生成 N'-[1-(2-hydroxyphenyl)ethylidene]-1H-indole-3-carbohydrazide
  参考文献：
  名称：

  Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes

  摘要：

  First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spiro-cyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.077

文献信息

• A polymer grafted oxidomethoxidovanadium(V) complex of an ONO donor ligand mimicking peroxidase activity
  作者：Mannar R. Maurya、Naveen Kumar、Nikita Chaudhary

  DOI：10.1016/j.poly.2015.05.010

  日期：2015.9

  the formation of K[V V O(O 2 )(hap-iah)] ( 2 ). Complex 1 has been grafted into chloromethylated polystyrene cross-linked with 5% divinylbenzene now abbreviated as PS-[V V O(OMe)(hap-iah)] ( 3 )} via covalent bonding through the imino nitrogen atom of the indole group. The two complexes have been characterized by various spectroscopic techniques (IR, electronic, 1 H, 13 C and 51 V NMR, ESI-MS), analytical

  摘要[V IV O（acac）2]与ONO供体三齿配体H 2 hap-iah（I）[H 2 hap-iah = Schiff碱通过等摩尔量的邻羟基苯乙酮（hap）的缩合反应）然后，在氧气气氛下，在回流的甲醇中，以等摩尔比使吲哚-3-乙酸酰肼（iah）]得到[VVO（OMe）（hap-iah）]（1）。在KOH存在下用H 2 O 2在甲醇中处理1会导致形成K [VVO（O 2）（hap-iah）]（2）。配合物1通过吲哚基的亚氨基氮原子通过共价键接枝到与5％二乙烯基苯交联的氯甲基化聚苯乙烯中（现在缩写为PS- [VVO（OMe）（hap-iah）]（3））。两种络合物已通过各种光谱技术（红外，电子，1 H，13 C和51 V NMR，ESI-MS），分析和热学研究进行了表征。还通过场发射扫描电子显微照片（FE-SEM）以及能量色散X射线（EDAX）研究分析了聚合物接枝的复合物3。聚合物接枝的配合物3已被用作在pH
• Sodium bicarbonate assisted oxidation, by H2O2, of styrene and cyclohexene using polymer grafted dioxidomolybdenum(VI) complex as a catalyst
  作者：Mannar R. Maurya、Naveen Kumar

  DOI：10.1016/j.molcata.2015.06.002

  日期：2015.9

  Ligand H(2)hap-iah (I), obtained by the condensation of equimolar amounts of o-hydroxy acetophenone (hap) and indole-3-acetic hydrazide (iah) reacts with [(MoO2)-O-vI(acac)2] in 1:1 ratio in refluxing methanol to give [(MoO2)-O-vI(hap-iah)(Me0H)] (I). Complex 1 has been grafted in chloromethylated polystyrene cross-linked with 5% divinylbenzene now abbreviated as PSAMo(vI)O(2)(hap-iah)(MeOH)] (2)1 via covalent bonding through imino nitrogen of the indole group. Both complexes are characterized by various spectroscopic techniques (IR, electronic, H-1, and C-13 NMR), analytical and thermal studies. Complex 2 has also been analyzed by atomic force microscopy (AFM), field-emission scanning electron micrographs (FE-SEM) as well as energy dispersive X-ray (EDAX) studies. The polymer-grafted compound 2 was used for the catalytic oxidation of styrene and cyclohexene in the presence of NaHCO3 using aqueous H2O2 as oxidant. The intermediate peroxido species, expected to be involved during catalytic action, was also generated from the solution of 1 and studied by UV-vis. Various reaction conditions were considered to optimize reactions conditions for the maximum oxidation of substrates. Styrene under optimized reaction conditions gave mainly styrene oxide as a major product. Oxidation of cyclohexene gave cyclohexene oxide selectively. The polymer-grafted complex shows higher conversions than its neat counterpart. The polymer-grafted complex provides additional advantage over its homogeneous counterpart in terms of increased catalyst lifetime and easier separation from the reaction mixture and allows for recyclable catalytic system. (C) 2015 Elsevier B.V. All rights reserved.
• Synthesis and Crystal Structure of a Phenolato-bridged Dinuclear Oxovanadium(V) Complex Derived from <i>N’</i>-[1-(2-Hydroxyphenyl)ethylidene]-1<i>H</i>-indole-3-carbohydrazide
  作者：San-Jun Peng、Ju-Lan Zeng、Chao Wei、Fang Fang

  DOI：10.1080/15533174.2011.591343

  日期：2011.9.1

  A tridentate ligand, N'-[1-(2-hydroxyphenyl)ethylidene]-1H-indole-3-carbohydrazide (H2L), reacts with vanadyl sulfate in methanol to give a centrosymmetric dinuclear complex, [VOL(OCH3)](2). The complex was characterized by physicochemical and spectroscopic methods. The crystal of the complex is monoclinic with space group P21/c, a = 8.345(3), b = 9.469(3), c = 24.087(4) angstrom, beta = 96.290(3)., V = 1892.1(9) angstrom(3), Z = 4. X-ray crystallography indicates that each V-V atom is in a distorted octahedral coordination. The two V atoms are bridged by two phenolate O atoms, with a distance of 3.540(2) angstrom.