2-Iod-4-methoxy-pyridin | 89640-54-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Iod-4-methoxy-pyridin
• 英文别名: 2-iodo-4-methoxypyridine
• CAS: 89640-54-0
• 化学式: C₆H₆INO
• 分子量: 235.024
• InChiKey: AAOGVCILTNNSPP-UHFFFAOYSA-N

物化性质

• 熔点：
  35 °C
• 沸点：
  274.0±20.0 °C(Predicted)
• 密度：
  1.825±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Iod-4-methoxy-pyridin 在 异丙基氯化镁 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 2.17h， 生成 methyl 4-methoxy-β-oxo-2-pyrimidinepropanoate
  参考文献：
  名称：

  Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099)

  摘要：

  AZD5099 (compound 63) is an antibacterial agent that entered phase 1 clinical trials targeting infections caused by Gram-positive and fastidious Gram-negative bacteria. It was derived from previously reported pyrrolamide antibacterials and a fragment-based approach targeting the ATP binding site of bacterial type II topoisomerases. The program described herein varied a 3-piperidine substituent and incorporated 4-thiazole substituents that form a seven-membered ring intramolecular hydrogen bond with a 5-position carboxylic acid. Improved antibacterial activity and lower in vivo clearances were achieved. The lower clearances were attributed, in part, to reduced recognition by the multidrug resistant transporter Mrp2. Compound 63 showed notable efficacy in a mouse neutropenic Staphylococcus aureus infection model. Resistance frequency versus the drug was low, and reports of clinical resistance due to alteration of the target are few. Hence, 63 could offer a novel treatment for serious issues of resistance to currently used antibacterials.

  DOI：

  10.1021/jm500462x
• 作为产物：
  描述：

  4-甲氧基吡啶 在 2,2,6,6-四甲基哌啶 、 正丁基锂 、 dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc 、 碘 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.0h， 生成 2-Iod-4-methoxy-pyridin
  参考文献：
  名称：

  利用去金属-碘解-N-芳基化序列合成N-吡啶基吡咯并评估其在黑素瘤细胞中的抗增殖活性

  摘要：

  通过铜催化在不同条件下研究了吡咯与3-碘-4-甲氧基吡啶的N-芳基化反应。最佳条件被证明是协议A（CuI，DMEDA或TMEDA，K 3 PO 4，DMF在110°C）以及最重要的协议B（Cu 2 O，Cs 2 CO 3，DMSO在110°C），用于合成各种N-（甲氧基吡啶基）吡咯，吲哚和苯并咪唑。通过评估从1开始的含碳碘上的部分正电荷，可以合理化不同碘化甲氧基吡啶的行为相应的脱碘底物的1 H NMR化学位移。接下来，将反应与去碘原化-碘分解步骤连接，生成碘化的甲氧基吡啶：粗的碘代中间体直接参与吡咯N-芳基化，以良好的产率提供了预期的N-（甲氧基吡啶基）吡咯。几种合成的N-（甲氧基吡啶基）唑在A2058黑色素瘤细胞中发挥低至中等的抗增殖活性。

  DOI：

  10.1016/j.tet.2016.08.056

文献信息

• NOVEL COMPOUNDS
  申请人：GRAUERT Matthias

  公开号：US20130184248A1

  公开（公告）日：2013-07-18

  This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R 1 , R 2 , R 3 have meanings given in the description.

  这项发明涉及到式I的化合物，它们作为mGlu5受体活性的正向变构调节剂的用途，含有这些化合物的药物组合物，以及将其用作治疗和/或预防与谷氨酸功能障碍相关的神经和精神疾病，如精神分裂症或认知功能下降，如痴呆症或认知障碍的药剂的方法。A、B、Ar、R1、R2、R3在描述中有给定的含义。
• [EN] SUBSTITUTED TRIAZOLES AND THEIR USE FOR TREATMENT AND/OR PREVENTION NEUROLOGICAL AND PSYCHIATRIC DISORDERS<br/>[FR] TRIAZOLES SUBSTITUÉS ET LEUR UTILISATION POUR LE TRAITEMENT ET/OU LA PRÉVENTION DE TROUBLES NEUROLOGIQUES ET PSYCHIATRIQUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013107761A1

  公开（公告）日：2013-07-25

  This invention relates to compounds of formula (I), their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

  这项发明涉及式(I)的化合物，它们作为mGlu5受体活性的正向变构调节剂的用途，含有这些化合物的药物组合物，以及将其用作治疗和/或预防与谷氨酸功能障碍相关的神经和精神疾病，如精神分裂症或认知功能下降，如痴呆症或认知障碍的药剂的方法。A、B、Ar、R1、R2、R3在描述中有给定的含义。
• [EN] 2-PYRIDYLOXY-4-ETHER OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES 2-PYRIDYLOXY-4-ÉTHER DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014137883A1

  公开（公告）日：2014-09-12

  The present invention is directed to 2-pyridyloxy-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ether compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved..

  本发明涉及2-吡啶氧基-4-醚化合物，这些化合物是促进睡眠的受体拮抗剂。本发明还涉及在潜在治疗或预防神经系统和精神疾病中使用本文所述的2-吡啶氧基-4-醚化合物。本发明还涉及包括这些化合物的药物组合物。本发明还涉及在预防或治疗涉及促进睡眠的受体的这些疾病中使用这些药物组合物。
• [EN] NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS<br/>[FR] ANALOGUES DE NUCLÉOSIDE POUR LE TRAITEMENT D'INFECTIONS PARASITAIRES
  申请人：UNIV GENT

  公开号：WO2019076633A1

  公开（公告）日：2019-04-25

  The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.

  本发明涉及新型核苷类似物和含有所述核苷类似物的组合物。此外，本发明提供了制备所述化合物的方法，以及使用它们的方法，例如作为药物，特别是用于诊断、预防和/或治疗寄生虫感染，更具体地用于诊断、预防和/或治疗Trypanosoma感染。
• Triphenylphosphine derivative, production process therefor, palladium complex thereof, and process for producing biaryl derivative
  申请人：——

  公开号：US20030065208A1

  公开（公告）日：2003-04-03

  Provided are a novel triphenyl phosphine derivative synthesized from a triphenylphosphine and a hydroxy-containing lactone; a palladium and a nickel complexes comprising the derivative as a ligand; and a process for preparing a biaryl derivative using the complex as a catalyst. A product can be easily separated from a catalyst or a phosphorus compound, and biaryl derivative can be synthesized in a higher yield, by using the complex of the present invention as a catalyst.

  提供了一种新型的三苯基膦衍生物，通过三苯基膦和含羟基的内酯合成；一种以该衍生物为配体的钯和镍配合物；以及一种利用该配合物作为催化剂制备联苯衍生物的方法。通过使用本发明的复合物作为催化剂，产品可以很容易地与催化剂或磷化合物分离，联苯衍生物可以以更高的产率合成。