5-sulfanylpentanyl α-L-rhamnopyranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-rhamnopyranoside | 1239318-60-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-sulfanylpentanyl α-L-rhamnopyranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-rhamnopyranoside
• 英文别名: (2S,3R,4R,5R,6S)-2-[(2S,3R,4R,5S,6S)-2-[(2R,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-2-(5-sulfanylpentoxy)oxan-3-yl]oxy-3,5-dihydroxy-6-methyloxan-4-yl]oxy-6-methyloxane-3,4,5-triol
• CAS: 1239318-60-5
• 化学式: C₂₃H₄₂O₁₃S
• 分子量: 558.645
• InChiKey: ZHIJHAKKHQHKAW-QUPZFLBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  198
• 氢给体数：
  8
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  5-thioacetylpentyl 2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl-(1->3)-2,4-di-O-acetyl-α-L-rhamnopyranosyl-(1->2)-3,4-di-O-acetyl-α-L-rhamnopyranoside 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以74%的产率得到5-sulfanylpentanyl α-L-rhamnopyranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-rhamnopyranoside
  参考文献：
  名称：

  Molecular Analysis of Carbohydrate−Antibody Interactions: Case Study Using a Bacillus anthracis Tetrasaccharide

  摘要：

  The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens.

  DOI：

  10.1021/ja104027w