2-(4-acridin-9-ylamino-phenoxy)-propionic acid | 80260-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4-acridin-9-ylamino-phenoxy)-propionic acid
• 英文别名: 2-[4-(Acridin-9-ylamino)phenoxy]propanoic acid
• CAS: 80260-15-7
• 化学式: C₂₂H₁₈N₂O₃
• 分子量: 358.397
• InChiKey: VJMLHHBJIAIQLB-UHFFFAOYSA-N

物化性质

• 沸点：
  562.4±40.0 °C(Predicted)
• 密度：
  1.332±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY
  申请人：Washington University

  公开号：US20200283820A1

  公开（公告）日：2020-09-10

  The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.
• [EN] IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADASE ACTIVITY<br/>[FR] IDENTIFICATION D'INHIBITEURS DE L'ACTIVITÉ NADASE DE TCPC ET DE TIR
  申请人：UNIV WASHINGTON

  公开号：WO2019067625A1

  公开（公告）日：2019-04-04

  The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.