p-methoxyphenyl β-D-galactofuranosyl-(1->3)-α-D-galactopyranosyl-(1->3)-β-D-galactofuranosyl-(1->3)-α-D-galactopyranosyl-(1->3)-β-D-galactofuranosyl-(1->3)-β-D-galactopyranoside | 1374633-18-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-methoxyphenyl β-D-galactofuranosyl-(1->3)-α-D-galactopyranosyl-(1->3)-β-D-galactofuranosyl-(1->3)-α-D-galactopyranosyl-(1->3)-β-D-galactofuranosyl-(1->3)-β-D-galactopyranoside
• 英文别名: Galf(b1-3)Gal(a1-3)Galf(b1-3)Gal(a1-3)Galf(b1-3)Gal(b)-O-Ph(4-OMe)；(2R,3R,4S,5S,6R)-2-[(2S,3R,4R,5R)-2-[(1R)-1,2-dihydroxyethyl]-5-[(2R,3R,4S,5S,6R)-2-[(2S,3R,4R,5R)-2-[(1R)-1,2-dihydroxyethyl]-5-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-(4-methoxyphenoxy)oxan-4-yl]oxy-4-hydroxyoxolan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxyoxolan-3-yl]oxy-4-[(2S,3R,4R,5S)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,5-diol
• CAS: 1374633-18-7
• 化学式: C₄₃H₆₈O₃₂
• 分子量: 1096.99
• InChiKey: WXTFCNIWOGCJMG-YWFVHBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.3
• 重原子数：
  75
• 可旋转键数：
  22
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  504
• 氢给体数：
  19
• 氢受体数：
  32

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 45.0 ℃ 、4.05 MPa 条件下， 反应 20.0h， 以26 mg的产率得到p-methoxyphenyl β-D-galactofuranosyl-(1->3)-α-D-galactopyranosyl-(1->3)-β-D-galactofuranosyl-(1->3)-α-D-galactopyranosyl-(1->3)-β-D-galactofuranosyl-(1->3)-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of tetra- and hexasaccharide fragments corresponding to the O-antigenic polysaccharide of Klebsiella pneumoniae

  摘要：

  The preparation of linear tetra- (1) and hexasaccharides (2), containing the repeating unit [-> 3)-beta-Galf-(1 -> 3)-alpha-Galp-(1 -> ] present in the O-polysaccharide of the lipopolysaccharide of Klebsiella pneumoniae is described. The key step in their synthesis is the alpha-selective galactopyranosylation of 3-OH di- and tetrasaccharide acceptors (20 and 22) with a disaccharide trichloroacetimidate donor 19 in the presence of trimethylsilyl triflate in a diethyl ether-CH2Cl2 mixture as solvent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.074