2,6-dihydroxy-heptanedioic acid diamide | 89941-24-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,6-dihydroxy-heptanedioic acid diamide
• 英文别名: 2,6-Dihydroxy-heptandisaeure-diamid；2,6-Dihydroxy-heptandiamid
• CAS: 89941-24-2
• 化学式: C₇H₁₄N₂O₄
• 分子量: 190.199
• InChiKey: GBRJQYLJJUGDJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.15
• 重原子数：
  13.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  126.64
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2,6-dioxoheptane-1,7-dicarboxylic acid 在 乙醇 、 氨 、 镍 、 苯 作用下， 100.0 ℃ 、9.81 MPa 条件下， 生成 2,6-dihydroxy-heptanedioic acid diamide
  参考文献：
  名称：

  Elimination of Latently HIV-1-Infected Cells by Lymphoblasts Armed with Bifunctional Antibody

  摘要：

  AbstractThe Fab′ fragment of a monoclonal antibody (mAb) to CD3 and the F(ab′)2 fragment of a mAb to human immunodeficiency virus 1 (HIV‐1) gp41 were combined to generate a bifunctional antibody (BFA). The mAb to gp41 (IV1‐4G6) has previously been shown to react with a number of HIV‐1 strains and T‐lymphoblastoid cells (TLBC) armed with the BFA (BFA‐TLBC) effectively inhibited HIV‐1 in primarily cultured lymphoblasts infected with the clinically isolated virus which was reactive to the mAb. Although BFA‐TLBC could not cause cytolysis of 51Cr‐labeled latently infected cells (OM‐10.1) in 6 hr incubation, cocultivation of OM‐10.1 cells with BFA‐TLBC for 3 days or more eliminated the latently infected cells making the cells susceptible to BFA‐TLBC. Therefore, BFA‐TLBC may be beneficial for HIV‐infected patients in eradicating latently infected cells which can not be eliminated even with highly active antiretroviral therapy (HAART).

  DOI：

  10.1111/j.1348-0421.2001.tb01266.x

文献信息

• Onno, Journal des Recherches du Centre National de la Recherche Scientifique, 1960, vol. 11, p. 205,225
  作者：Onno

  DOI：——

  日期：——