2,6-dioxoheptane-1,7-dicarboxylic acid | 34457-84-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2,6-dioxoheptane-1,7-dicarboxylic acid
• 英文别名: α,α'-dioxopimelic acid；2,6-Dioxopimelinsaeure；2,6-dioxo-heptanedioic acid；2,6-Dioxo-heptandisaeure；2,6-Dioxoheptanedioic acid
• CAS: 34457-84-6
• 化学式: C₇H₈O₆
• 分子量: 188.137
• InChiKey: DYOMGPBEPIHZAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,6-dioxoheptane-1,7-dicarboxylic acid 在 乙醇 、 氨 、 镍 、 苯 作用下， 100.0 ℃ 、9.81 MPa 条件下， 生成 2,6-dihydroxy-heptanedioic acid diamide
  参考文献：
  名称：

  Elimination of Latently HIV-1-Infected Cells by Lymphoblasts Armed with Bifunctional Antibody

  摘要：

  AbstractThe Fab′ fragment of a monoclonal antibody (mAb) to CD3 and the F(ab′)2 fragment of a mAb to human immunodeficiency virus 1 (HIV‐1) gp41 were combined to generate a bifunctional antibody (BFA). The mAb to gp41 (IV1‐4G6) has previously been shown to react with a number of HIV‐1 strains and T‐lymphoblastoid cells (TLBC) armed with the BFA (BFA‐TLBC) effectively inhibited HIV‐1 in primarily cultured lymphoblasts infected with the clinically isolated virus which was reactive to the mAb. Although BFA‐TLBC could not cause cytolysis of 51Cr‐labeled latently infected cells (OM‐10.1) in 6 hr incubation, cocultivation of OM‐10.1 cells with BFA‐TLBC for 3 days or more eliminated the latently infected cells making the cells susceptible to BFA‐TLBC. Therefore, BFA‐TLBC may be beneficial for HIV‐infected patients in eradicating latently infected cells which can not be eliminated even with highly active antiretroviral therapy (HAART).

  DOI：

  10.1111/j.1348-0421.2001.tb01266.x
• 作为产物：
  描述：

  bis-(2,4,5-trioxo-tetrahydro-[3]furyl)-methane 在 水 作用下， 反应 0.5h， 生成 2,6-dioxoheptane-1,7-dicarboxylic acid
  参考文献：
  名称：

  Synthesis of a key intermediate in the diaminopimelate pathway to L-Lysine: 2,3,4,5-tetrahydrodipicolinic acid

  摘要：

  2,3,4,5-Tetrahydrodipicolinic acid (3) is a key intermediate in the diaminopimelate (DAP) pathway to L-lysine (7). It was synthesized as the stable racemic potassium salt (25) from dipicolinic acid (14) by esterification, hydrogenation to the cis-diester (17), followed by elimination of p-toluenesuifinic acid from the N-toluenesulfonyl derivative (24) of dimethyl cis-piperidine-2,6-dicarboxylate with concomitant cleavage of the ester groups. (+/-)-2,3,4,5-Tetrahydrodipicolinic acid is unstable in neutral or acidic solution, and in basic solution it exists in equilibrium with the corresponding enamine (27) and 2-oxo-6-aminoadipate (26).

  DOI：

  10.1016/0040-4020(95)00618-i

文献信息

• [EN] COMPOUNDS USEFUL AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS UTILES COMME IMMUNOMODULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015034820A1

  公开（公告）日：2015-03-12

  Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.

  揭示了化合物的化学式（I）：（I）。还公开了使用这些化合物作为免疫调节剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或减缓病毒性疾病或紊乱以及癌症的进展方面具有用处。
• COMPOUNDS USEFUL AS IMMUNOMODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160194307A1

  公开（公告）日：2016-07-07

  Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.

  本发明公开了一种公式（I）的化合物：（I）。还公开了使用这种化合物作为免疫调节剂的方法，以及包含这种化合物的制药组合物。这些化合物可用于治疗、预防或减缓病毒性疾病或障碍和癌症的进展。
• Al-Hassan, Saieba S.; Kulick, Russell J.; Livingstone, Daniel B., Journal of the Chemical Society. Perkin transactions I, 1980, p. 2645 - 2656
  作者：Al-Hassan, Saieba S.、Kulick, Russell J.、Livingstone, Daniel B.、Suckling, Colin J.、Wood, Hamish C. S.、Wrigglesworth, Roger、Ferone, Robert

  DOI：——

  日期：——
• Hahn; Hansel, Chemische Berichte, 1938, vol. 71, p. 2163,2172
  作者：Hahn、Hansel

  DOI：——

  日期：——
• Carbon Alkylations with 1-Methylgramine and its Methiodide
  作者：H. R. Snyder、Ernest L. Eliel

  DOI：10.1021/ja01170a079

  日期：1949.2