6-([4-methoxy-1,1'-biphenyl]-2-yl)-9-β-D-(2',3',5'-tri-O-acetyl)ribofuranosyl-9H-purine | 1284287-23-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-([4-methoxy-1,1'-biphenyl]-2-yl)-9-β-D-(2',3',5'-tri-O-acetyl)ribofuranosyl-9H-purine
• CAS: 1284287-23-5
• 化学式: C₂₉H₂₈N₄O₈
• 分子量: 560.563
• InChiKey: CDLXBPZESBLOQV-FLKHEUMLSA-N

反应信息

• 作为产物：
  描述：

  碘苯 、 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-6-(3-methoxyphenyl)purine 在 silver(I) acetate 、 palladium diacetate 、 溶剂黄146 作用下， 反应 48.0h， 以87%的产率得到6-([4-methoxy-1,1'-biphenyl]-2-yl)-9-β-D-(2',3',5'-tri-O-acetyl)ribofuranosyl-9H-purine
  参考文献：
  名称：

  Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C−H Activation: A New Strategy for Modification of 6-Arylpurine Derivatives

  摘要：

  Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-arylpurines with simple aryl iodides via C H bond activation in good yields, providing a complementary tool for the modification of 6-arylpurines (nucleosides). Most importantly, purine can be used as a building block for nucleoside derivatives, and the use of purine as a directing group helps avoid additional synthetic steps.

  DOI：

  10.1021/ol200405w